FRG1B protein (Homo sapiens) - STRING network view

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FRG1B

FSHD region gene 1 family, member B (182 aa)

Predicted Functional Partners:

CCDC144A

0.702

FAM182B

0.700

KPNA6

0.613

CDC40

0.523

PRPF19

0.523

SEPT7L

0.509

ZCCHC7

0.480

TBL3

0.471

ZCCHC10

0.461

PRKRIP1

0.459

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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... protein annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC144A	FAM182B	ENSP00000353717	ENSP00000365585	coiled-coil domain containing 144A	family with sequence similarity 182, member B	0.700
CCDC144A	FRG1B	ENSP00000353717	ENSP00000278882	coiled-coil domain containing 144A	FSHD region gene 1 family, member B	0.702
CCDC144A	TBL3	ENSP00000353717	ENSP00000454836	coiled-coil domain containing 144A	transducin (beta)-like 3	0.507
CDC40	FRG1B	ENSP00000304370	ENSP00000278882	cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing	FSHD region gene 1 family, member B	0.523
CDC40	PRPF19	ENSP00000304370	ENSP00000227524	cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...]	0.998
FAM182B	CCDC144A	ENSP00000365585	ENSP00000353717	family with sequence similarity 182, member B	coiled-coil domain containing 144A	0.700
FAM182B	FRG1B	ENSP00000365585	ENSP00000278882	family with sequence similarity 182, member B	FSHD region gene 1 family, member B	0.700
FAM182B	TBL3	ENSP00000365585	ENSP00000454836	family with sequence similarity 182, member B	transducin (beta)-like 3	0.461
FRG1B	CCDC144A	ENSP00000278882	ENSP00000353717	FSHD region gene 1 family, member B	coiled-coil domain containing 144A	0.702
FRG1B	CDC40	ENSP00000278882	ENSP00000304370	FSHD region gene 1 family, member B	cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing	0.523
FRG1B	FAM182B	ENSP00000278882	ENSP00000365585	FSHD region gene 1 family, member B	family with sequence similarity 182, member B	0.700
FRG1B	KPNA6	ENSP00000278882	ENSP00000362728	FSHD region gene 1 family, member B	karyopherin alpha 6 (importin alpha 7); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...]	0.613
FRG1B	PRKRIP1	ENSP00000278882	ENSP00000381010	FSHD region gene 1 family, member B	PRKR interacting protein 1 (IL11 inducible); Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity)	0.459
FRG1B	PRPF19	ENSP00000278882	ENSP00000227524	FSHD region gene 1 family, member B	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...]	0.523
FRG1B	SEPT7L	ENSP00000278882	ENSP00000239730	FSHD region gene 1 family, member B	septin 7-like	0.509
FRG1B	TBL3	ENSP00000278882	ENSP00000454836	FSHD region gene 1 family, member B	transducin (beta)-like 3	0.471
FRG1B	ZCCHC10	ENSP00000278882	ENSP00000324274	FSHD region gene 1 family, member B	zinc finger, CCHC domain containing 10	0.461
FRG1B	ZCCHC7	ENSP00000278882	ENSP00000337839	FSHD region gene 1 family, member B	zinc finger, CCHC domain containing 7	0.480
KPNA6	FRG1B	ENSP00000362728	ENSP00000278882	karyopherin alpha 6 (importin alpha 7); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...]	FSHD region gene 1 family, member B	0.613
PRKRIP1	FRG1B	ENSP00000381010	ENSP00000278882	PRKR interacting protein 1 (IL11 inducible); Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity)	FSHD region gene 1 family, member B	0.459

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