| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CEP135 | NEDD1 | ENSP00000257287 | ENSP00000451211 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle | 0.943 |
| CEP135 | NEK2 | ENSP00000257287 | ENSP00000355966 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | NIMA-related kinase 2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex [...] | 0.944 |
| CEP135 | NINL | ENSP00000257287 | ENSP00000278886 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | ninein-like; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis | 0.932 |
| CEP135 | OFD1 | ENSP00000257287 | ENSP00000344314 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | oral-facial-digital syndrome 1; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis (By similarity) | 0.902 |
| CEP135 | PLK1 | ENSP00000257287 | ENSP00000300093 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | 0.938 |
| CEP135 | TUBG1 | ENSP00000257287 | ENSP00000251413 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | tubulin, gamma 1; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation | 0.976 |
| CEP135 | TUBGCP4 | ENSP00000257287 | ENSP00000456648 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | tubulin, gamma complex associated protein 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.910 |
| CEP135 | YWHAE | ENSP00000257287 | ENSP00000264335 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.900 |
| LCA5 | NINL | ENSP00000358861 | ENSP00000278886 | Leber congenital amaurosis 5; Might be involved in minus end-directed microtubule transport | ninein-like; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis | 0.960 |
| LCA5 | OFD1 | ENSP00000358861 | ENSP00000344314 | Leber congenital amaurosis 5; Might be involved in minus end-directed microtubule transport | oral-facial-digital syndrome 1; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis (By similarity) | 0.606 |
| LCA5 | TUBGCP4 | ENSP00000358861 | ENSP00000456648 | Leber congenital amaurosis 5; Might be involved in minus end-directed microtubule transport | tubulin, gamma complex associated protein 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.740 |
| LCA5 | USH2A | ENSP00000358861 | ENSP00000305941 | Leber congenital amaurosis 5; Might be involved in minus end-directed microtubule transport | Usher syndrome 2A (autosomal recessive, mild); Involved in hearing and vision | 0.680 |
| NEDD1 | CEP135 | ENSP00000451211 | ENSP00000257287 | neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | 0.943 |
| NEDD1 | NEK2 | ENSP00000451211 | ENSP00000355966 | neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle | NIMA-related kinase 2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex [...] | 0.927 |
| NEDD1 | NINL | ENSP00000451211 | ENSP00000278886 | neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle | ninein-like; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis | 0.932 |
| NEDD1 | OFD1 | ENSP00000451211 | ENSP00000344314 | neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle | oral-facial-digital syndrome 1; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis (By similarity) | 0.906 |
| NEDD1 | PLK1 | ENSP00000451211 | ENSP00000300093 | neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | 0.989 |
| NEDD1 | TUBG1 | ENSP00000451211 | ENSP00000251413 | neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle | tubulin, gamma 1; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation | 0.951 |
| NEDD1 | TUBGCP4 | ENSP00000451211 | ENSP00000456648 | neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle | tubulin, gamma complex associated protein 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.978 |
| NEDD1 | YWHAE | ENSP00000451211 | ENSP00000264335 | neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.903 |
Share
