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STRINGSTRING
KIF5B KIF5B KIF5C KIF5C NEK1 NEK1 SCOC SCOC KIF3A KIF3A DISC1 DISC1 FEZ1 FEZ1 ST8SIA2 ST8SIA2 NBR1 NBR1 UBE4B UBE4B ULK1 ULK1
"FEZ1" - fasciculation and elongation protein zeta 1 (zygin I) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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protein homology
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FEZ1fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules (392 aa)    
Predicted Functional Partners:
SCOC
short coiled-coil protein (159 aa)
        score_image   score_image   0.988
DISC1
disrupted in schizophrenia 1 (755 aa)
        score_image   score_image   0.959
NBR1
neighbor of BRCA1 gene 1; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets (966 aa)
        score_image   score_image   0.932
KIF5C
kinesin family member 5C (957 aa)
            score_image   0.909
KIF3A
kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) (699 aa)
            score_image   0.829
KIF5B
kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity) (963 aa)
            score_image   0.813
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression (375 aa)
            score_image   0.801
NEK1
NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly (1286 aa)
        score_image   score_image   0.682
UBE4B
ubiquitination factor E4B; Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3 (By similarity) (1302 aa)
        score_image   score_image   0.672
ULK1
unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...] (1050 aa)
        score_image   score_image   0.637
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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