| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANGPT2 | CSF1R | ENSP00000314897 | ENSP00000286301 | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | colony stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone [...] | 0.843 |
| ANGPT2 | ESAM | ENSP00000314897 | ENSP00000278927 | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | 0.897 |
| ANGPT2 | ICAM1 | ENSP00000314897 | ENSP00000264832 | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus | 0.896 |
| ANGPT2 | SELE | ENSP00000314897 | ENSP00000331736 | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | selectin E; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis | 0.738 |
| ATIC | ESAM | ENSP00000236959 | ENSP00000278927 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | 0.813 |
| ATIC | PPARG | ENSP00000236959 | ENSP00000287820 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | peroxisome proliferator-activated receptor gamma | 0.520 |
| CLDN5 | ESAM | ENSP00000384554 | ENSP00000278927 | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | 0.893 |
| CSF1R | ANGPT2 | ENSP00000286301 | ENSP00000314897 | colony stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone [...] | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | 0.843 |
| CSF1R | ESAM | ENSP00000286301 | ENSP00000278927 | colony stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone [...] | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | 0.843 |
| CSF1R | ICAM1 | ENSP00000286301 | ENSP00000264832 | colony stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone [...] | intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus | 0.889 |
| ESAM | ANGPT2 | ENSP00000278927 | ENSP00000314897 | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | 0.897 |
| ESAM | ATIC | ENSP00000278927 | ENSP00000236959 | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | 0.813 |
| ESAM | CLDN5 | ENSP00000278927 | ENSP00000384554 | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.893 |
| ESAM | CSF1R | ENSP00000278927 | ENSP00000286301 | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | colony stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone [...] | 0.843 |
| ESAM | ICAM1 | ENSP00000278927 | ENSP00000264832 | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus | 0.815 |
| ESAM | PPARG | ENSP00000278927 | ENSP00000287820 | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | peroxisome proliferator-activated receptor gamma | 0.859 |
| ESAM | SELE | ENSP00000278927 | ENSP00000331736 | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | selectin E; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis | 0.954 |
| ESAM | SELL | ENSP00000278927 | ENSP00000236147 | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | selectin L; Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity) | 0.937 |
| ESAM | SELP | ENSP00000278927 | ENSP00000263686 | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | selectin P (granule membrane protein 140kDa, antigen CD62); Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1 | 0.948 |
| ESAM | SELPLG | ENSP00000278927 | ENSP00000228463 | endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity) | selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture | 0.917 |
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