MYL9 protein (Homo sapiens) - STRING network view

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MYL9

myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (172 aa)

Predicted Functional Partners:

MYH14

0.999

PPP1R12A

0.998

MYLK

0.998

MYH9

0.994

ROCK2

0.993

PPP1R12C

0.993

ROCK1

0.990

RHOA

0.990

MYLK3

0.987

MYH11

0.987

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MYH11	MYH14	ENSP00000379616	ENSP00000262269	myosin, heavy chain 11, smooth muscle; Muscle contraction	myosin, heavy chain 14, non-muscle	0.902
MYH11	MYH9	ENSP00000379616	ENSP00000216181	myosin, heavy chain 11, smooth muscle; Muscle contraction	myosin, heavy chain 9, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping	0.900
MYH11	MYL9	ENSP00000379616	ENSP00000279022	myosin, heavy chain 11, smooth muscle; Muscle contraction	myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion	0.987
MYH11	MYLK	ENSP00000379616	ENSP00000353452	myosin, heavy chain 11, smooth muscle; Muscle contraction	myosin light chain kinase	0.959
MYH11	PPP1R12A	ENSP00000379616	ENSP00000261207	myosin, heavy chain 11, smooth muscle; Muscle contraction	protein phosphatase 1, regulatory subunit 12A; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity	0.582
MYH11	PPP1R12C	ENSP00000379616	ENSP00000263433	myosin, heavy chain 11, smooth muscle; Muscle contraction	protein phosphatase 1, regulatory subunit 12C; Regulates myosin phosphatase activity	0.518
MYH11	RHOA	ENSP00000379616	ENSP00000400175	myosin, heavy chain 11, smooth muscle; Muscle contraction	ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...]	0.971
MYH11	ROCK1	ENSP00000379616	ENSP00000382697	myosin, heavy chain 11, smooth muscle; Muscle contraction	Rho-associated, coiled-coil containing protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induc [...]	0.950
MYH11	ROCK2	ENSP00000379616	ENSP00000317985	myosin, heavy chain 11, smooth muscle; Muscle contraction	Rho-associated, coiled-coil containing protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MA [...]	0.966
MYH14	MYH11	ENSP00000262269	ENSP00000379616	myosin, heavy chain 14, non-muscle	myosin, heavy chain 11, smooth muscle; Muscle contraction	0.902
MYH14	MYH9	ENSP00000262269	ENSP00000216181	myosin, heavy chain 14, non-muscle	myosin, heavy chain 9, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping	0.952
MYH14	MYL9	ENSP00000262269	ENSP00000279022	myosin, heavy chain 14, non-muscle	myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion	0.999
MYH14	MYLK	ENSP00000262269	ENSP00000353452	myosin, heavy chain 14, non-muscle	myosin light chain kinase	0.982
MYH14	MYLK3	ENSP00000262269	ENSP00000378288	myosin, heavy chain 14, non-muscle	myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity)	0.965
MYH14	PPP1R12A	ENSP00000262269	ENSP00000261207	myosin, heavy chain 14, non-muscle	protein phosphatase 1, regulatory subunit 12A; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity	0.968
MYH14	PPP1R12C	ENSP00000262269	ENSP00000263433	myosin, heavy chain 14, non-muscle	protein phosphatase 1, regulatory subunit 12C; Regulates myosin phosphatase activity	0.888
MYH14	RHOA	ENSP00000262269	ENSP00000400175	myosin, heavy chain 14, non-muscle	ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...]	0.997
MYH14	ROCK1	ENSP00000262269	ENSP00000382697	myosin, heavy chain 14, non-muscle	Rho-associated, coiled-coil containing protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induc [...]	0.993
MYH14	ROCK2	ENSP00000262269	ENSP00000317985	myosin, heavy chain 14, non-muscle	Rho-associated, coiled-coil containing protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MA [...]	0.948
MYH9	MYH11	ENSP00000216181	ENSP00000379616	myosin, heavy chain 9, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping	myosin, heavy chain 11, smooth muscle; Muscle contraction	0.900

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