GPHA2 protein (Homo sapiens) - STRING network view

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GPHA2

glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production (129 aa)

Predicted Functional Partners:

PPP2R5B

0.760

TSHB

0.589

LHB

0.563

FSHR

0.562

VWC2L

0.511

PRL

0.459

LHCGR

0.418

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FSHR	GPHA2	ENSP00000384708	ENSP00000279168	follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	0.562
FSHR	LHB	ENSP00000384708	ENSP00000221421	follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	luteinizing hormone beta polypeptide; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids	0.547
FSHR	LHCGR	ENSP00000384708	ENSP00000294954	follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	0.903
FSHR	TSHB	ENSP00000384708	ENSP00000256592	follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	thyroid stimulating hormone, beta; Indispensable for the control of thyroid structure and metabolism	0.691
GPHA2	FSHR	ENSP00000279168	ENSP00000384708	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	0.562
GPHA2	LHB	ENSP00000279168	ENSP00000221421	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	luteinizing hormone beta polypeptide; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids	0.563
GPHA2	LHCGR	ENSP00000279168	ENSP00000294954	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	0.418
GPHA2	PPP2R5B	ENSP00000279168	ENSP00000164133	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	protein phosphatase 2, regulatory subunit B’, beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the ’Thr-308’ and ’Ser-373’ residues	0.760
GPHA2	PRL	ENSP00000279168	ENSP00000302150	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	prolactin; Prolactin acts primarily on the mammary gland by promoting lactation	0.459
GPHA2	TSHB	ENSP00000279168	ENSP00000256592	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	thyroid stimulating hormone, beta; Indispensable for the control of thyroid structure and metabolism	0.589
GPHA2	VWC2L	ENSP00000279168	ENSP00000308976	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	von Willebrand factor C domain containing protein 2-like; May play a role in neurogenesis (By similarity). May play a role in bone differentiation and matrix mineralization (By similarity)	0.511
LHB	FSHR	ENSP00000221421	ENSP00000384708	luteinizing hormone beta polypeptide; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids	follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	0.547
LHB	GPHA2	ENSP00000221421	ENSP00000279168	luteinizing hormone beta polypeptide; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	0.563
LHB	LHCGR	ENSP00000221421	ENSP00000294954	luteinizing hormone beta polypeptide; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids	luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	0.979
LHCGR	FSHR	ENSP00000294954	ENSP00000384708	luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	follicle stimulating hormone receptor; Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	0.903
LHCGR	GPHA2	ENSP00000294954	ENSP00000279168	luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	0.418
LHCGR	LHB	ENSP00000294954	ENSP00000221421	luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	luteinizing hormone beta polypeptide; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids	0.979
LHCGR	TSHB	ENSP00000294954	ENSP00000256592	luteinizing hormone/choriogonadotropin receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase	thyroid stimulating hormone, beta; Indispensable for the control of thyroid structure and metabolism	0.457
PPP2R5B	GPHA2	ENSP00000164133	ENSP00000279168	protein phosphatase 2, regulatory subunit B’, beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the ’Thr-308’ and ’Ser-373’ residues	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	0.760
PRL	GPHA2	ENSP00000302150	ENSP00000279168	prolactin; Prolactin acts primarily on the mammary gland by promoting lactation	glycoprotein hormone alpha 2; Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production	0.459

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