ARID5B protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ARID5B

AT rich interactive domain 5B (MRF1-like) (1188 aa)

Predicted Functional Partners:

CEBPE

0.748

C16orf87

0.651

HDAC1

0.650

UBC

0.622

HDAC2

0.619

SIPA1L2

0.568

IKZF1

0.560

BBX

0.558

FREM2

0.535

FRAS1

0.524

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID5B	BBX	ENSP00000279873	ENSP00000319974	AT rich interactive domain 5B (MRF1-like)	bobby sox homolog (Drosophila); Transcription factor that is necessary for cell cycle progression from G1 to S phase	0.558
ARID5B	C16orf87	ENSP00000279873	ENSP00000285697	AT rich interactive domain 5B (MRF1-like)	chromosome 16 open reading frame 87	0.651
ARID5B	CEBPE	ENSP00000279873	ENSP00000206513	AT rich interactive domain 5B (MRF1-like)	CCAAT/enhancer binding protein (C/EBP), epsilon; C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers	0.748
ARID5B	FRAS1	ENSP00000279873	ENSP00000264895	AT rich interactive domain 5B (MRF1-like)	Fraser syndrome 1	0.524
ARID5B	FREM2	ENSP00000279873	ENSP00000280481	AT rich interactive domain 5B (MRF1-like)	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	0.535
ARID5B	HDAC1	ENSP00000279873	ENSP00000362649	AT rich interactive domain 5B (MRF1-like)	histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...]	0.650
ARID5B	HDAC2	ENSP00000279873	ENSP00000430432	AT rich interactive domain 5B (MRF1-like)	histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...]	0.619
ARID5B	IKZF1	ENSP00000279873	ENSP00000331614	AT rich interactive domain 5B (MRF1-like)	IKAROS family zinc finger 1 (Ikaros); Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a si [...]	0.560
ARID5B	SIPA1L2	ENSP00000279873	ENSP00000262861	AT rich interactive domain 5B (MRF1-like)	signal-induced proliferation-associated 1 like 2	0.568
ARID5B	UBC	ENSP00000279873	ENSP00000344818	AT rich interactive domain 5B (MRF1-like)	ubiquitin C	0.622
BBX	ARID5B	ENSP00000319974	ENSP00000279873	bobby sox homolog (Drosophila); Transcription factor that is necessary for cell cycle progression from G1 to S phase	AT rich interactive domain 5B (MRF1-like)	0.558
BBX	C16orf87	ENSP00000319974	ENSP00000285697	bobby sox homolog (Drosophila); Transcription factor that is necessary for cell cycle progression from G1 to S phase	chromosome 16 open reading frame 87	0.646
C16orf87	ARID5B	ENSP00000285697	ENSP00000279873	chromosome 16 open reading frame 87	AT rich interactive domain 5B (MRF1-like)	0.651
C16orf87	BBX	ENSP00000285697	ENSP00000319974	chromosome 16 open reading frame 87	bobby sox homolog (Drosophila); Transcription factor that is necessary for cell cycle progression from G1 to S phase	0.646
C16orf87	HDAC1	ENSP00000285697	ENSP00000362649	chromosome 16 open reading frame 87	histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...]	0.615
C16orf87	HDAC2	ENSP00000285697	ENSP00000430432	chromosome 16 open reading frame 87	histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...]	0.615
CEBPE	ARID5B	ENSP00000206513	ENSP00000279873	CCAAT/enhancer binding protein (C/EBP), epsilon; C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers	AT rich interactive domain 5B (MRF1-like)	0.748
CEBPE	IKZF1	ENSP00000206513	ENSP00000331614	CCAAT/enhancer binding protein (C/EBP), epsilon; C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers	IKAROS family zinc finger 1 (Ikaros); Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a si [...]	0.472
FRAS1	ARID5B	ENSP00000264895	ENSP00000279873	Fraser syndrome 1	AT rich interactive domain 5B (MRF1-like)	0.524
FREM2	ARID5B	ENSP00000280481	ENSP00000279873	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	AT rich interactive domain 5B (MRF1-like)	0.535

page 1 of 3

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About