Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | KIAA1328 | KIAA1328 (577 aa) | ||||||||||||
Predicted Functional Partners:
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 | ZNF860 | zinc finger protein 860; May be involved in transcriptional regulation (By similarity) (632 aa) |
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0.703 | ||||||||||
 | BOD1L1 | biorientation of chromosomes in cell division 1-like 1 (3051 aa) |
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0.580 | ||||||||||
 | ZBTB2 | zinc finger and BTB domain containing 2; May be involved in transcriptional regulation (514 aa) |
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0.503 | ||||||||||
 | L2HGDH | L-2-hydroxyglutarate dehydrogenase (463 aa) |
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0.472 | ||||||||||
 | ENSG00000258447 | ATP synthase coupling factor B-like 1; ATP synthase subunit s, mitochondrial; Uncharacterized protein (266 aa) |
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0.470 | ||||||||||
 | MTNR1A | melatonin receptor 1A; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity (350 aa) |
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0.459 | ||||||||||
 | ZNF396 | zinc finger protein 396; Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors (333 aa) |
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0.459 | ||||||||||
 | bA251O17.4 | Uncharacterized protein (92 aa) |
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0.450 | ||||||||||
 | CELF4 | CUGBP, Elav-like family member 4; RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sit [...] (486 aa) |
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0.412 | ||||||||||
 | ATP5S | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B); Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity) (215 aa) |
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0.407 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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