node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPI | GCH1 | ENSP00000295463 | ENSP00000378890 | alkaline phosphatase, intestinal | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | 0.903 |
ALPI | PTS | ENSP00000295463 | ENSP00000280362 | alkaline phosphatase, intestinal | 6-pyruvoyltetrahydropterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin | 0.900 |
ALPL | GCH1 | ENSP00000363965 | ENSP00000378890 | alkaline phosphatase, liver/bone/kidney | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | 0.903 |
ALPL | PTS | ENSP00000363965 | ENSP00000280362 | alkaline phosphatase, liver/bone/kidney | 6-pyruvoyltetrahydropterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin | 0.900 |
ALPP | ALPPL2 | ENSP00000375881 | ENSP00000295453 | alkaline phosphatase, placental | alkaline phosphatase, placental-like 2 | 0.581 |
ALPP | GCH1 | ENSP00000375881 | ENSP00000378890 | alkaline phosphatase, placental | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | 0.903 |
ALPP | PTS | ENSP00000375881 | ENSP00000280362 | alkaline phosphatase, placental | 6-pyruvoyltetrahydropterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin | 0.900 |
ALPPL2 | ALPP | ENSP00000295453 | ENSP00000375881 | alkaline phosphatase, placental-like 2 | alkaline phosphatase, placental | 0.581 |
ALPPL2 | GCH1 | ENSP00000295453 | ENSP00000378890 | alkaline phosphatase, placental-like 2 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | 0.903 |
ALPPL2 | PTS | ENSP00000295453 | ENSP00000280362 | alkaline phosphatase, placental-like 2 | 6-pyruvoyltetrahydropterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin | 0.900 |
GCH1 | ALPI | ENSP00000378890 | ENSP00000295463 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | alkaline phosphatase, intestinal | 0.903 |
GCH1 | ALPL | ENSP00000378890 | ENSP00000363965 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | alkaline phosphatase, liver/bone/kidney | 0.903 |
GCH1 | ALPP | ENSP00000378890 | ENSP00000375881 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | alkaline phosphatase, placental | 0.903 |
GCH1 | ALPPL2 | ENSP00000378890 | ENSP00000295453 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | alkaline phosphatase, placental-like 2 | 0.903 |
GCH1 | GCHFR | ENSP00000378890 | ENSP00000260447 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | GTP cyclohydrolase I feedback regulator; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine | 0.999 |
GCH1 | PTS | ENSP00000378890 | ENSP00000280362 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | 6-pyruvoyltetrahydropterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin | 0.978 |
GCH1 | SPR | ENSP00000378890 | ENSP00000234454 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | sepiapterin reductase (7,8-dihydrobiopterin-NADP+ oxidoreductase); Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin | 0.827 |
GCHFR | GCH1 | ENSP00000260447 | ENSP00000378890 | GTP cyclohydrolase I feedback regulator; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | 0.999 |
GCHFR | PTS | ENSP00000260447 | ENSP00000280362 | GTP cyclohydrolase I feedback regulator; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine | 6-pyruvoyltetrahydropterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin | 0.927 |
GCHFR | SPR | ENSP00000260447 | ENSP00000234454 | GTP cyclohydrolase I feedback regulator; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine | sepiapterin reductase (7,8-dihydrobiopterin-NADP+ oxidoreductase); Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin | 0.457 |