Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
ALPI ALPI GCHFR GCHFR SPR SPR GCH1 GCH1 ALPP ALPP PRKG2 PRKG2 PTS PTS ALPL ALPL ALPPL2 ALPPL2 STAT1 STAT1 PDGFRB PDGFRB
"PTS" - 6-pyruvoyltetrahydropterin synthase in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTS6-pyruvoyltetrahydropterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin (145 aa)    
Predicted Functional Partners:
GCH1
GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown (250 aa)
score_image         score_image score_image   0.978
SPR
sepiapterin reductase (7,8-dihydrobiopterin-NADP+ oxidoreductase); Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin (261 aa)
          score_image score_image   0.974
PRKG2
protein kinase, cGMP-dependent, type II (762 aa)
        score_image score_image score_image   0.960
GCHFR
GTP cyclohydrolase I feedback regulator; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (84 aa)
          score_image score_image   0.927
ALPP
alkaline phosphatase, placental (535 aa)
          score_image     0.900
ALPL
alkaline phosphatase, liver/bone/kidney (524 aa)
          score_image     0.900
ALPI
alkaline phosphatase, intestinal (528 aa)
          score_image     0.900
ALPPL2
alkaline phosphatase, placental-like 2 (532 aa)
          score_image     0.900
PDGFRB
platelet-derived growth factor receptor, beta polypeptide; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of n [...] (1106 aa)
            score_image   0.873
STAT1
signal transducer and activator of transcription 1, 91kDa (750 aa)
            score_image   0.866
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (31%)