FREM2 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

FREM2

FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion (3169 aa)

Predicted Functional Partners:

NPNT

0.829

GRIP1

0.681

MRPL23

0.628

TRPC4

0.608

TCF12

0.564

ZC3H11A

0.546

MYO7B

0.541

ARID5B

0.535

SLC30A8

0.533

SLC30A2

0.533

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID5B	FREM2	ENSP00000279873	ENSP00000280481	AT rich interactive domain 5B (MRF1-like)	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	0.535
ARID5B	MYO7B	ENSP00000279873	ENSP00000386461	AT rich interactive domain 5B (MRF1-like)	myosin VIIB; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia (By similarity)	0.481
FREM2	ARID5B	ENSP00000280481	ENSP00000279873	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	AT rich interactive domain 5B (MRF1-like)	0.535
FREM2	GRIP1	ENSP00000280481	ENSP00000381098	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	glutamate receptor interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons	0.681
FREM2	MRPL23	ENSP00000280481	ENSP00000370930	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	mitochondrial ribosomal protein L23	0.628
FREM2	MYO7B	ENSP00000280481	ENSP00000386461	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	myosin VIIB; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia (By similarity)	0.541
FREM2	NPNT	ENSP00000280481	ENSP00000389252	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	nephronectin	0.829
FREM2	SLC30A2	ENSP00000280481	ENSP00000363394	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	solute carrier family 30 (zinc transporter), member 2	0.533
FREM2	SLC30A8	ENSP00000280481	ENSP00000415011	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	solute carrier family 30 (zinc transporter), member 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells	0.533
FREM2	TCF12	ENSP00000280481	ENSP00000331057	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’)	0.564
FREM2	TRPC4	ENSP00000280481	ENSP00000369003	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	transient receptor potential cation channel, subfamily C, member 4	0.608
FREM2	ZC3H11A	ENSP00000280481	ENSP00000333253	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	zinc finger CCCH-type containing 11A	0.546
GRIP1	FREM2	ENSP00000381098	ENSP00000280481	glutamate receptor interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	0.681
MRPL23	FREM2	ENSP00000370930	ENSP00000280481	mitochondrial ribosomal protein L23	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	0.628
MYO7B	ARID5B	ENSP00000386461	ENSP00000279873	myosin VIIB; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia (By similarity)	AT rich interactive domain 5B (MRF1-like)	0.481
MYO7B	FREM2	ENSP00000386461	ENSP00000280481	myosin VIIB; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia (By similarity)	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	0.541
MYO7B	ZC3H11A	ENSP00000386461	ENSP00000333253	myosin VIIB; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia (By similarity)	zinc finger CCCH-type containing 11A	0.563
NPNT	FREM2	ENSP00000389252	ENSP00000280481	nephronectin	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	0.829
SLC30A2	FREM2	ENSP00000363394	ENSP00000280481	solute carrier family 30 (zinc transporter), member 2	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	0.533
SLC30A8	FREM2	ENSP00000415011	ENSP00000280481	solute carrier family 30 (zinc transporter), member 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells	FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	0.533

page 1 of 2

Experiments

Cooccurrence

Textmining

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About