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STRINGSTRING
FEZ2 FEZ2 IKZF5 IKZF5 GOPC GOPC PAPLN PAPLN KCNK1 KCNK1 CRIM1 CRIM1 RACGAP1 RACGAP1 VEGFA VEGFA BMP7 BMP7 BMP4 BMP4 GLIPR1 GLIPR1
"CRIM1" - cysteine rich transmembrane BMP regulator 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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protein homology
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CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like); May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (1036 aa)    
Predicted Functional Partners:
BMP4
bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) (408 aa)
            score_image   0.930
BMP7
bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (431 aa)
            score_image   0.919
GLIPR1
GLI pathogenesis-related 1 (266 aa)
        score_image   score_image   0.864
PAPLN
papilin, proteoglycan-like sulfated glycoprotein (1251 aa)
        score_image   score_image   0.861
FEZ2
fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) (380 aa)
            score_image   0.860
IKZF5
IKAROS family zinc finger 5 (Pegasus); DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor (419 aa)
        score_image       0.858
GOPC
golgi-associated PDZ and coiled-coil motif containing; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes (462 aa)
        score_image       0.858
KCNK1
potassium channel, subfamily K, member 1; Weakly inward rectifying potassium channel (336 aa)
        score_image       0.858
RACGAP1
Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] (632 aa)
        score_image       0.858
VEGFA
vascular endothelial growth factor A (412 aa)
            score_image   0.831
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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