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GOT1 GOT1 GOT2 GOT2 ME1 ME1 LDHC LDHC ME2 ME2 ACLY ACLY PKM PKM ME3 ME3 PDHA2 PDHA2 PDHA1 PDHA1 PDHB PDHB
"LDHC" - lactate dehydrogenase C in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
large protein node
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
LDHClactate dehydrogenase C; Possible role in sperm motility (332 aa)    
Predicted Functional Partners:
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] (413 aa)
      score_image   score_image score_image   0.984
GOT2
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (430 aa)
      score_image   score_image score_image   0.984
PKM
pyruvate kinase, muscle (531 aa)
      score_image score_image score_image score_image   0.984
ACLY
ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
score_image     score_image score_image   score_image   0.977
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial (604 aa)
score_image     score_image score_image score_image score_image   0.976
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic (572 aa)
score_image     score_image score_image score_image score_image   0.974
ME2
malic enzyme 2, NAD(+)-dependent, mitochondrial (584 aa)
score_image     score_image score_image score_image score_image   0.971
PDHA2
pyruvate dehydrogenase (lipoamide) alpha 2; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle (388 aa)
      score_image   score_image score_image   0.968
PDHB
pyruvate dehydrogenase (lipoamide) beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle (359 aa)
      score_image score_image score_image score_image   0.956
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1 (428 aa)
      score_image   score_image score_image   0.952
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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