Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | BTBD11 | BTB (POZ) domain containing 11 (1104 aa) | ||||||||||||
Predicted Functional Partners:
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 | ALKBH6 | alkB, alkylation repair homolog 6 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity) (266 aa) |
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0.571 | |||||||||
 | NEDD9 | neural precursor cell expressed, developmentally down-regulated 9; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK [...] (834 aa) |
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0.527 | ||||||||||
 | ENSG00000263264 | Uncharacterized protein (382 aa) |
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0.485 | ||||||||||
 | ZBTB5 | zinc finger and BTB domain containing 5; May be involved in transcriptional regulation (677 aa) |
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0.485 | ||||||||||
 | NOP16 | NOP16 nucleolar protein homolog (yeast) (178 aa) |
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0.483 | ||||||||||
 | TTLL9 | tubulin tyrosine ligase-like family, member 9; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity) (439 aa) |
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0.472 | ||||||||||
 | GADL1 | glutamate decarboxylase-like 1 (521 aa) |
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0.472 | ||||||||||
 | ZSCAN22 | zinc finger and SCAN domain containing 22; May be involved in transcriptional regulation (491 aa) |
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0.464 | ||||||||||
 | COMMD7 | COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity (200 aa) |
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0.459 | ||||||||||
 | WDR17 | WD repeat domain 17 (1322 aa) |
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0.456 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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