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STRINGSTRING
JUP JUP PKP3 PKP3 CDX2 CDX2 PKP2 PKP2 DSP DSP DSC2 DSC2 DSG2 DSG2 CDX1 CDX1 KRT16 KRT16 KRTAP5-4 KRTAP5-4 FOXN1 FOXN1
"DSC2" - desmocollin 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
DSC2desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms (901 aa)    
Predicted Functional Partners:
PKP2
plakophilin 2; May play a role in junctional plaques (881 aa)
        score_image   score_image   0.965
PKP3
plakophilin 3; May play a role in junctional plaques (797 aa)
        score_image   score_image   0.955
JUP
junction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhes [...] (745 aa)
        score_image   score_image   0.941
FOXN1
forkhead box N1; Transcriptional regulator involved in development (648 aa)
            score_image   0.907
DSP
desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes (2871 aa)
        score_image   score_image   0.889
KRT16
keratin 16 (473 aa)
            score_image   0.887
DSG2
desmoglein 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (1118 aa)
      score_image score_image   score_image score_image 0.859
CDX1
caudal type homeobox 1; Could play a role in the terminal differentiation of the intestine (265 aa)
            score_image   0.854
CDX2
caudal type homeobox 2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine (313 aa)
            score_image   0.842
KRTAP5-4
keratin associated protein 5-4 (228 aa)
            score_image   0.836
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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