node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP13 | AKAP6 | ENSP00000354718 | ENSP00000280979 | A kinase (PRKA) anchor protein 13 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | 0.887 |
AKAP13 | AKAP9 | ENSP00000354718 | ENSP00000348573 | A kinase (PRKA) anchor protein 13 | A kinase (PRKA) anchor protein (yotiao) 9 | 0.561 |
AKAP13 | PDE4A | ENSP00000354718 | ENSP00000270474 | A kinase (PRKA) anchor protein 13 | phosphodiesterase 4A, cAMP-specific | 0.454 |
AKAP13 | PRKAR2A | ENSP00000354718 | ENSP00000265563 | A kinase (PRKA) anchor protein 13 | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.992 |
AKAP13 | RAPGEF3 | ENSP00000354718 | ENSP00000373864 | A kinase (PRKA) anchor protein 13 | Rap guanine nucleotide exchange factor (GEF) 3; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis | 0.461 |
AKAP6 | AKAP13 | ENSP00000280979 | ENSP00000354718 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | A kinase (PRKA) anchor protein 13 | 0.887 |
AKAP6 | AKAP9 | ENSP00000280979 | ENSP00000348573 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | A kinase (PRKA) anchor protein (yotiao) 9 | 0.888 |
AKAP6 | HIF1A | ENSP00000280979 | ENSP00000338018 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...] | 0.817 |
AKAP6 | PDE4A | ENSP00000280979 | ENSP00000270474 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | phosphodiesterase 4A, cAMP-specific | 0.877 |
AKAP6 | PDE4D | ENSP00000280979 | ENSP00000345502 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | phosphodiesterase 4D, cAMP-specific | 0.810 |
AKAP6 | PRKAR2A | ENSP00000280979 | ENSP00000265563 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.819 |
AKAP6 | RAPGEF3 | ENSP00000280979 | ENSP00000373864 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | Rap guanine nucleotide exchange factor (GEF) 3; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis | 0.961 |
AKAP6 | RYR2 | ENSP00000280979 | ENSP00000355533 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | ryanodine receptor 2 (cardiac); Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development | 0.985 |
AKAP6 | SRC | ENSP00000280979 | ENSP00000350941 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.858 |
AKAP6 | SYNPO2 | ENSP00000280979 | ENSP00000306015 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | synaptopodin 2; Has an actin-binding and actin-bundling activity (By similarity) | 0.812 |
AKAP9 | AKAP13 | ENSP00000348573 | ENSP00000354718 | A kinase (PRKA) anchor protein (yotiao) 9 | A kinase (PRKA) anchor protein 13 | 0.561 |
AKAP9 | AKAP6 | ENSP00000348573 | ENSP00000280979 | A kinase (PRKA) anchor protein (yotiao) 9 | A kinase (PRKA) anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes | 0.888 |
AKAP9 | PDE4A | ENSP00000348573 | ENSP00000270474 | A kinase (PRKA) anchor protein (yotiao) 9 | phosphodiesterase 4A, cAMP-specific | 0.501 |
AKAP9 | PRKAR2A | ENSP00000348573 | ENSP00000265563 | A kinase (PRKA) anchor protein (yotiao) 9 | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.992 |
AKAP9 | RAPGEF3 | ENSP00000348573 | ENSP00000373864 | A kinase (PRKA) anchor protein (yotiao) 9 | Rap guanine nucleotide exchange factor (GEF) 3; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis | 0.471 |