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GNPDA2 GNPDA2 KCTD15 KCTD15 NEGR1 NEGR1 FTO FTO BCDIN3D BCDIN3D SH2B1 SH2B1 SEC16B SEC16B MTCH2 MTCH2 TMEM18 TMEM18 MC4R MC4R YY1 YY1
"TMEM18" - transmembrane protein 18 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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experimentally determined
Predicted Interactions
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fusion edge
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protein homology
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TMEM18transmembrane protein 18; Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC) (140 aa)    
Predicted Functional Partners:
GNPDA2
glucosamine-6-phosphate deaminase 2 (276 aa)
             score_image   0.870
KCTD15
potassium channel tetramerisation domain containing 15 (283 aa)
             score_image   0.824
SEC16B
SEC16 homolog B (S. cerevisiae); Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization (1060 aa)
             score_image   0.818
FTO
fat mass and obesity associated; Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and ener [...] (505 aa)
             score_image   0.817
MTCH2
mitochondrial carrier 2; The substrate transported is not yet known. Induces mitochondrial depolarization (303 aa)
             score_image   0.815
NEGR1
neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity) (354 aa)
             score_image   0.813
SH2B1
SH2B adaptor protein 1; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated (’Tyr-813’) JAK2 recruits SH2B1, which in turn is phosphoryla [...] (756 aa)
             score_image   0.813
MC4R
melanocortin 4 receptor; Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase (332 aa)
             score_image   0.811
YY1
YY1 transcription factor; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5’-CCGCCATNTT-3’; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repre [...] (414 aa)
             score_image   0.800
BCDIN3D
BCDIN3 domain containing; O-methyltransferase that specifically dimethylates the 5’ monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5’ monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing- methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre- miRNAs (292 aa)
             score_image   0.752
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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