NUBPL protein (Homo sapiens) - STRING network view

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NUBPL

nucleotide binding protein-like; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits (319 aa)

Predicted Functional Partners:

NARFL

0.907

NARF

0.892

FOXRED1

0.846

IBA57

0.744

MTUS2

0.692

ISCU

0.677

HSCB

0.675

NDUFAF3

0.672

BOLA3

0.672

NDUFA11

0.660

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOLA3	HSCB	ENSP00000331369	ENSP00000216027	bolA homolog 3 (E. coli)	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	0.675
BOLA3	IBA57	ENSP00000331369	ENSP00000355672	bolA homolog 3 (E. coli)	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity)	0.728
BOLA3	ISCU	ENSP00000331369	ENSP00000310623	bolA homolog 3 (E. coli)	iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron	0.482
BOLA3	NUBPL	ENSP00000331369	ENSP00000281081	bolA homolog 3 (E. coli)	nucleotide binding protein-like; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits	0.672
FOXRED1	NDUFA11	ENSP00000263578	ENSP00000389160	FAD-dependent oxidoreductase domain containing 1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)	0.561
FOXRED1	NDUFAF3	ENSP00000263578	ENSP00000323076	FAD-dependent oxidoreductase domain containing 1	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; Essential factor for the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I)	0.560
FOXRED1	NUBPL	ENSP00000263578	ENSP00000281081	FAD-dependent oxidoreductase domain containing 1	nucleotide binding protein-like; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits	0.846
HSCB	BOLA3	ENSP00000216027	ENSP00000331369	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	bolA homolog 3 (E. coli)	0.675
HSCB	IBA57	ENSP00000216027	ENSP00000355672	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity)	0.754
HSCB	ISCU	ENSP00000216027	ENSP00000310623	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron	0.999
HSCB	NUBPL	ENSP00000216027	ENSP00000281081	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	nucleotide binding protein-like; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits	0.675
IBA57	BOLA3	ENSP00000355672	ENSP00000331369	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity)	bolA homolog 3 (E. coli)	0.728
IBA57	HSCB	ENSP00000355672	ENSP00000216027	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity)	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	0.754
IBA57	ISCU	ENSP00000355672	ENSP00000310623	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity)	iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron	0.750
IBA57	NUBPL	ENSP00000355672	ENSP00000281081	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity)	nucleotide binding protein-like; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits	0.744
ISCU	BOLA3	ENSP00000310623	ENSP00000331369	iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron	bolA homolog 3 (E. coli)	0.482
ISCU	HSCB	ENSP00000310623	ENSP00000216027	iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron	HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria	0.999
ISCU	IBA57	ENSP00000310623	ENSP00000355672	iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity)	0.750
ISCU	NARFL	ENSP00000310623	ENSP00000251588	iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron	nuclear prelamin A recognition factor-like; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect	0.576
ISCU	NUBPL	ENSP00000310623	ENSP00000281081	iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron	nucleotide binding protein-like; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits	0.677

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