node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PGF | PIGF | ENSP00000451040 | ENSP00000281382 | placental growth factor; Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth | phosphatidylinositol glycan anchor biosynthesis, class F; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity) | 0.811 |
PIGA | PIGB | ENSP00000369820 | ENSP00000164305 | phosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | 0.855 |
PIGA | PIGC | ENSP00000369820 | ENSP00000258324 | phosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class C; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | 0.993 |
PIGA | PIGF | ENSP00000369820 | ENSP00000281382 | phosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class F; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity) | 0.864 |
PIGA | PIGG | ENSP00000369820 | ENSP00000415203 | phosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class G | 0.700 |
PIGA | PIGK | ENSP00000369820 | ENSP00000359848 | phosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class K; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein’s C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein | 0.705 |
PIGA | PIGO | ENSP00000369820 | ENSP00000339382 | phosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity) | 0.728 |
PIGA | PIGT | ENSP00000369820 | ENSP00000279036 | phosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class T | 0.923 |
PIGA | PIGU | ENSP00000369820 | ENSP00000217446 | phosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class U; Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI | 0.524 |
PIGB | PIGA | ENSP00000164305 | ENSP00000369820 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis | 0.855 |
PIGB | PIGC | ENSP00000164305 | ENSP00000258324 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class C; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | 0.637 |
PIGB | PIGF | ENSP00000164305 | ENSP00000281382 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class F; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity) | 0.971 |
PIGB | PIGG | ENSP00000164305 | ENSP00000415203 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class G | 0.724 |
PIGB | PIGK | ENSP00000164305 | ENSP00000359848 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class K; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein’s C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein | 0.680 |
PIGB | PIGO | ENSP00000164305 | ENSP00000339382 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity) | 0.969 |
PIGB | PIGU | ENSP00000164305 | ENSP00000217446 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class U; Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI | 0.407 |
PIGC | PIGA | ENSP00000258324 | ENSP00000369820 | phosphatidylinositol glycan anchor biosynthesis, class C; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis | 0.993 |
PIGC | PIGB | ENSP00000258324 | ENSP00000164305 | phosphatidylinositol glycan anchor biosynthesis, class C; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | 0.637 |
PIGC | PIGF | ENSP00000258324 | ENSP00000281382 | phosphatidylinositol glycan anchor biosynthesis, class C; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class F; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity) | 0.816 |
PIGC | PIGG | ENSP00000258324 | ENSP00000415203 | phosphatidylinositol glycan anchor biosynthesis, class C; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | phosphatidylinositol glycan anchor biosynthesis, class G | 0.655 |