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GDF5 GDF5 BMP2 BMP2 BMP4 BMP4 HES6 HES6 CREB1 CREB1 MYOD1 MYOD1 BARX2 BARX2 CDH6 CDH6 CDH10 CDH10 GDF6 GDF6 TBL1X TBL1X
"BARX2" - BARX homeobox 2 in Homo sapiens
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BARX2BARX homeobox 2; Transcription factor. Binds optimally to the DNA consensus sequence 5’-YYTAATGRTTTTY-3’. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity) (279 aa)    
Predicted Functional Partners:
CREB1
cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (341 aa)
        score_image   score_image   0.880
HES6
hairy and enhancer of split 6 (Drosophila); Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity) (224 aa)
            score_image   0.842
MYOD1
myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) (320 aa)
            score_image   0.839
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (790 aa)
            score_image   0.818
BMP4
bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) (408 aa)
            score_image   0.807
GDF5
growth differentiation factor 5; Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B (501 aa)
            score_image   0.806
CDH10
cadherin 10, type 2 (T2-cadherin); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (788 aa)
            score_image   0.698
BMP2
bone morphogenetic protein 2; Induces cartilage and bone formation (396 aa)
            score_image   0.690
GDF6
growth differentiation factor 6; Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development (By similarity) (455 aa)
            score_image   0.667
TBL1X
transducin (beta)-like 1X-linked; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (577 aa)
        score_image   score_image   0.652
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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