| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDH1 | CGN | ENSP00000261769 | ENSP00000271636 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier | 0.581 |
| CDH1 | CLDN2 | ENSP00000261769 | ENSP00000336571 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | claudin 2; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | 0.623 |
| CDH1 | CTTN | ENSP00000261769 | ENSP00000365745 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases | 0.989 |
| CDH1 | GJA1 | ENSP00000261769 | ENSP00000282561 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | gap junction protein, alpha 1, 43kDa; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity- acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural s [...] | 0.624 |
| CDH1 | MLLT4 | ENSP00000261769 | ENSP00000375956 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.439 |
| CDH1 | OCLN | ENSP00000261769 | ENSP00000347379 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | occludin | 0.817 |
| CDH1 | TJP1 | ENSP00000261769 | ENSP00000281537 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.997 |
| CDH1 | TJP2 | ENSP00000261769 | ENSP00000438262 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | tight junction protein 2 | 0.704 |
| CGN | CDH1 | ENSP00000271636 | ENSP00000261769 | cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | 0.581 |
| CGN | CLDN2 | ENSP00000271636 | ENSP00000336571 | cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier | claudin 2; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | 0.928 |
| CGN | CSDA | ENSP00000271636 | ENSP00000228251 | cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier | cold shock domain protein A; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5’-UCCAUCA-3’. May have a role in translation repression (By similarity) | 0.626 |
| CGN | MLLT4 | ENSP00000271636 | ENSP00000375956 | cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.926 |
| CGN | OCLN | ENSP00000271636 | ENSP00000347379 | cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier | occludin | 0.968 |
| CGN | TJP1 | ENSP00000271636 | ENSP00000281537 | cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.999 |
| CGN | TJP2 | ENSP00000271636 | ENSP00000438262 | cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier | tight junction protein 2 | 0.998 |
| CLDN2 | CDH1 | ENSP00000336571 | ENSP00000261769 | claudin 2; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | 0.623 |
| CLDN2 | CGN | ENSP00000336571 | ENSP00000271636 | claudin 2; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier | 0.928 |
| CLDN2 | CSDA | ENSP00000336571 | ENSP00000228251 | claudin 2; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | cold shock domain protein A; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5’-UCCAUCA-3’. May have a role in translation repression (By similarity) | 0.885 |
| CLDN2 | OCLN | ENSP00000336571 | ENSP00000347379 | claudin 2; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | occludin | 0.870 |
| CLDN2 | TJP1 | ENSP00000336571 | ENSP00000281537 | claudin 2; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.996 |
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