node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH5A1 | FAM8A1 | ENSP00000314649 | ENSP00000259963 | aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) | family with sequence similarity 8, member A1 | 0.601 |
ALDH5A1 | PARP8 | ENSP00000314649 | ENSP00000281631 | aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) | poly (ADP-ribose) polymerase family, member 8 | 0.485 |
FAM8A1 | ALDH5A1 | ENSP00000259963 | ENSP00000314649 | family with sequence similarity 8, member A1 | aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) | 0.601 |
FAM8A1 | PARP8 | ENSP00000259963 | ENSP00000281631 | family with sequence similarity 8, member A1 | poly (ADP-ribose) polymerase family, member 8 | 0.627 |
PARP10 | PARP8 | ENSP00000325618 | ENSP00000281631 | poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression | poly (ADP-ribose) polymerase family, member 8 | 0.649 |
PARP10 | TNKS | ENSP00000325618 | ENSP00000311579 | poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex- poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequ [...] | 0.561 |
PARP10 | TNKS2 | ENSP00000325618 | ENSP00000360689 | poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex- poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subseque [...] | 0.569 |
PARP11 | PARP8 | ENSP00000228820 | ENSP00000281631 | poly (ADP-ribose) polymerase family, member 11 | poly (ADP-ribose) polymerase family, member 8 | 0.520 |
PARP14 | PARP8 | ENSP00000418194 | ENSP00000281631 | poly (ADP-ribose) polymerase family, member 14; Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity | poly (ADP-ribose) polymerase family, member 8 | 0.597 |
PARP14 | PARP9 | ENSP00000418194 | ENSP00000353512 | poly (ADP-ribose) polymerase family, member 14; Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity | poly (ADP-ribose) polymerase family, member 9; In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes | 0.767 |
PARP15 | PARP8 | ENSP00000417214 | ENSP00000281631 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | poly (ADP-ribose) polymerase family, member 8 | 0.581 |
PARP15 | PARP9 | ENSP00000417214 | ENSP00000353512 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | poly (ADP-ribose) polymerase family, member 9; In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes | 0.509 |
PARP8 | ALDH5A1 | ENSP00000281631 | ENSP00000314649 | poly (ADP-ribose) polymerase family, member 8 | aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) | 0.485 |
PARP8 | FAM8A1 | ENSP00000281631 | ENSP00000259963 | poly (ADP-ribose) polymerase family, member 8 | family with sequence similarity 8, member A1 | 0.627 |
PARP8 | PARP10 | ENSP00000281631 | ENSP00000325618 | poly (ADP-ribose) polymerase family, member 8 | poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression | 0.649 |
PARP8 | PARP11 | ENSP00000281631 | ENSP00000228820 | poly (ADP-ribose) polymerase family, member 8 | poly (ADP-ribose) polymerase family, member 11 | 0.520 |
PARP8 | PARP14 | ENSP00000281631 | ENSP00000418194 | poly (ADP-ribose) polymerase family, member 8 | poly (ADP-ribose) polymerase family, member 14; Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity | 0.597 |
PARP8 | PARP15 | ENSP00000281631 | ENSP00000417214 | poly (ADP-ribose) polymerase family, member 8 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | 0.581 |
PARP8 | PARP9 | ENSP00000281631 | ENSP00000353512 | poly (ADP-ribose) polymerase family, member 8 | poly (ADP-ribose) polymerase family, member 9; In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes | 0.532 |
PARP8 | PPWD1 | ENSP00000281631 | ENSP00000261308 | poly (ADP-ribose) polymerase family, member 8 | peptidylprolyl isomerase domain and WD repeat containing 1; Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing | 0.488 |