Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | KANSL1L | KAT8 regulatory NSL complex subunit 1-like (987 aa) | ||||||||||||
Predicted Functional Partners:
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 | OR51Q1 | olfactory receptor, family 51, subfamily Q, member 1; Odorant receptor (Potential) (317 aa) |
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0.649 | ||||||||||
 | C1orf216 | chromosome 1 open reading frame 216 (229 aa) |
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0.644 | ||||||||||
 | CCDC64B | coiled-coil domain containing 64B (508 aa) |
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0.538 | ||||||||||
 | MSL1 | male-specific lethal 1 homolog (Drosophila); Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at ’Lys-16’ (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at ’Lys-34’ (H2BK34Ub). This modification in turn stimulates histone H3 methylation at ’Lys-4’ (H3K4me) and ’Lys-79’ (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (351 aa) |
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0.504 | ||||||||||
 | C2orf73 | chromosome 2 open reading frame 73 (287 aa) |
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0.504 | ||||||||||
 | TRIM61 | tripartite motif containing 61 (209 aa) |
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0.504 | ||||||||||
 | KRTAP2-3 | keratin associated protein 2-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (By similarity) (128 aa) |
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0.472 | ||||||||||
 | MRGPRF | MAS-related GPR, member F; Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity) (343 aa) |
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0.459 | ||||||||||
 | LRRTM1 | leucine rich repeat transmembrane neuronal 1; Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level (By similarity) (522 aa) |
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0.412 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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