MCHR2 protein (Homo sapiens) - STRING network view

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MCHR2

melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis (340 aa)

Predicted Functional Partners:

PMCH

0.971

GNAQ

0.952

SST

0.925

NPS

0.920

XCL1

0.920

NPY

0.917

CNR1

0.917

GAL

0.916

POMC

0.916

UTS2R

0.915

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNR1	GAL	ENSP00000358511	ENSP00000265643	cannabinoid receptor 1 (brain)	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	0.931
CNR1	MCHR2	ENSP00000358511	ENSP00000281806	cannabinoid receptor 1 (brain)	melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis	0.917
CNR1	NPS	ENSP00000358511	ENSP00000381105	cannabinoid receptor 1 (brain)	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.581
CNR1	NPY	ENSP00000358511	ENSP00000242152	cannabinoid receptor 1 (brain)	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.956
CNR1	PMCH	ENSP00000358511	ENSP00000332225	cannabinoid receptor 1 (brain)	pro-melanin-concentrating hormone; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation	0.929
CNR1	POMC	ENSP00000358511	ENSP00000264708	cannabinoid receptor 1 (brain)	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.954
CNR1	SST	ENSP00000358511	ENSP00000287641	cannabinoid receptor 1 (brain)	somatostatin; Somatostatin inhibits the release of somatotropin	0.951
GAL	CNR1	ENSP00000265643	ENSP00000358511	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	cannabinoid receptor 1 (brain)	0.931
GAL	MCHR2	ENSP00000265643	ENSP00000281806	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis	0.916
GAL	NPS	ENSP00000265643	ENSP00000381105	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.879
GAL	NPY	ENSP00000265643	ENSP00000242152	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.990
GAL	PMCH	ENSP00000265643	ENSP00000332225	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	pro-melanin-concentrating hormone; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation	0.914
GAL	POMC	ENSP00000265643	ENSP00000264708	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.971
GAL	SST	ENSP00000265643	ENSP00000287641	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	somatostatin; Somatostatin inhibits the release of somatotropin	0.981
GNAQ	MCHR2	ENSP00000286548	ENSP00000281806	guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity)	melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis	0.952
GNAQ	NPS	ENSP00000286548	ENSP00000381105	guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity)	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.927
GNAQ	PMCH	ENSP00000286548	ENSP00000332225	guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity)	pro-melanin-concentrating hormone; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation	0.900
GNAQ	UTS2R	ENSP00000286548	ENSP00000323516	guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity)	urotensin 2 receptor; High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system	0.905
GNAQ	XCL1	ENSP00000286548	ENSP00000356792	guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity)	chemokine (C motif) ligand 1; Chemotactic activity for lymphocytes but not for monocytes or neutrophils	0.900
MCHR2	CNR1	ENSP00000281806	ENSP00000358511	melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis	cannabinoid receptor 1 (brain)	0.917

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