| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BAG3 | HSPB1 | ENSP00000358081 | ENSP00000248553 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | heat shock 27kDa protein 1 | 0.556 |
| BAG3 | HSPB8 | ENSP00000358081 | ENSP00000281938 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | heat shock 22kDa protein 8; Displays temperature-dependent chaperone activity | 0.956 |
| BMPR1A | HSPB8 | ENSP00000224764 | ENSP00000281938 | bone morphogenetic protein receptor, type IA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 | heat shock 22kDa protein 8; Displays temperature-dependent chaperone activity | 0.779 |
| BMPR1A | MAP3K7 | ENSP00000224764 | ENSP00000358335 | bone morphogenetic protein receptor, type IA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 | mitogen-activated protein kinase kinase kinase 7 | 0.931 |
| CCND1 | HSPB1 | ENSP00000227507 | ENSP00000248553 | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | heat shock 27kDa protein 1 | 0.453 |
| CCND1 | HSPB2 | ENSP00000227507 | ENSP00000457706 | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK | 0.418 |
| CCND1 | HSPB3 | ENSP00000227507 | ENSP00000303394 | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | heat shock 27kDa protein 3; Inhibitor of actin polymerization | 0.416 |
| CCND1 | HSPB8 | ENSP00000227507 | ENSP00000281938 | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | heat shock 22kDa protein 8; Displays temperature-dependent chaperone activity | 0.819 |
| CCND1 | KHDRBS1 | ENSP00000227507 | ENSP00000313829 | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | KH domain containing, RNA binding, signal transduction associated 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA n [...] | 0.854 |
| HSPB1 | BAG3 | ENSP00000248553 | ENSP00000358081 | heat shock 27kDa protein 1 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | 0.556 |
| HSPB1 | CCND1 | ENSP00000248553 | ENSP00000227507 | heat shock 27kDa protein 1 | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | 0.453 |
| HSPB1 | HSPB8 | ENSP00000248553 | ENSP00000281938 | heat shock 27kDa protein 1 | heat shock 22kDa protein 8; Displays temperature-dependent chaperone activity | 0.925 |
| HSPB1 | MAP3K7 | ENSP00000248553 | ENSP00000358335 | heat shock 27kDa protein 1 | mitogen-activated protein kinase kinase kinase 7 | 0.589 |
| HSPB1 | MN1 | ENSP00000248553 | ENSP00000304956 | heat shock 27kDa protein 1 | meningioma (disrupted in balanced translocation) 1; May play a role in tumor suppression | 0.482 |
| HSPB2 | CCND1 | ENSP00000457706 | ENSP00000227507 | HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | 0.418 |
| HSPB2 | HSPB3 | ENSP00000457706 | ENSP00000303394 | HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK | heat shock 27kDa protein 3; Inhibitor of actin polymerization | 0.648 |
| HSPB2 | HSPB8 | ENSP00000457706 | ENSP00000281938 | HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK | heat shock 22kDa protein 8; Displays temperature-dependent chaperone activity | 0.854 |
| HSPB3 | CCND1 | ENSP00000303394 | ENSP00000227507 | heat shock 27kDa protein 3; Inhibitor of actin polymerization | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | 0.416 |
| HSPB3 | HSPB2 | ENSP00000303394 | ENSP00000457706 | heat shock 27kDa protein 3; Inhibitor of actin polymerization | HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK | 0.648 |
| HSPB3 | HSPB7 | ENSP00000303394 | ENSP00000310111 | heat shock 27kDa protein 3; Inhibitor of actin polymerization | heat shock 27kDa protein family, member 7 (cardiovascular) | 0.845 |
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