Export your current network:
... as a bitmap image:
file format is 'PNG': portable network graphic
... as a high-resolution bitmap:
same PNG format, but resolution at 400 dpi
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as simple tabular text output:
TSV: tab separated values - can be opened in Excel
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAM179A | RNF219 | ENSP00000368876 | ENSP00000282003 | family with sequence similarity 179, member A | ring finger protein 219 | 0.564 |
| LLPH | RNF219 | ENSP00000266604 | ENSP00000282003 | LLP homolog, long-term synaptic facilitation (Aplysia) | ring finger protein 219 | 0.503 |
| MAP7D1 | RNF219 | ENSP00000362244 | ENSP00000282003 | MAP7 domain containing 1 | ring finger protein 219 | 0.504 |
| MAP7D1 | UBC | ENSP00000362244 | ENSP00000344818 | MAP7 domain containing 1 | ubiquitin C | 0.809 |
| NLK | RNF219 | ENSP00000384625 | ENSP00000282003 | nemo-like kinase; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis [...] | ring finger protein 219 | 0.525 |
| NLK | UBC | ENSP00000384625 | ENSP00000344818 | nemo-like kinase; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis [...] | ubiquitin C | 0.801 |
| RNF169 | RNF187 | ENSP00000299563 | ENSP00000306396 | ring finger protein 169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair | ring finger protein 187; E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8 | 0.501 |
| RNF169 | RNF219 | ENSP00000299563 | ENSP00000282003 | ring finger protein 169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair | ring finger protein 219 | 0.502 |
| RNF169 | UBC | ENSP00000299563 | ENSP00000344818 | ring finger protein 169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair | ubiquitin C | 0.878 |
| RNF169 | USP41 | ENSP00000299563 | ENSP00000414922 | ring finger protein 169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair | ubiquitin specific peptidase 41; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity) | 0.416 |
| RNF187 | RNF169 | ENSP00000306396 | ENSP00000299563 | ring finger protein 187; E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8 | ring finger protein 169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair | 0.501 |
| RNF187 | RNF219 | ENSP00000306396 | ENSP00000282003 | ring finger protein 187; E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8 | ring finger protein 219 | 0.581 |
| RNF187 | UBC | ENSP00000306396 | ENSP00000344818 | ring finger protein 187; E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8 | ubiquitin C | 0.837 |
| RNF187 | USP41 | ENSP00000306396 | ENSP00000414922 | ring finger protein 187; E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8 | ubiquitin specific peptidase 41; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity) | 0.509 |
| RNF219 | FAM179A | ENSP00000282003 | ENSP00000368876 | ring finger protein 219 | family with sequence similarity 179, member A | 0.564 |
| RNF219 | LLPH | ENSP00000282003 | ENSP00000266604 | ring finger protein 219 | LLP homolog, long-term synaptic facilitation (Aplysia) | 0.503 |
| RNF219 | MAP7D1 | ENSP00000282003 | ENSP00000362244 | ring finger protein 219 | MAP7 domain containing 1 | 0.504 |
| RNF219 | NLK | ENSP00000282003 | ENSP00000384625 | ring finger protein 219 | nemo-like kinase; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis [...] | 0.525 |
| RNF219 | RNF169 | ENSP00000282003 | ENSP00000299563 | ring finger protein 219 | ring finger protein 169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair | 0.502 |
| RNF219 | RNF187 | ENSP00000282003 | ENSP00000306396 | ring finger protein 219 | ring finger protein 187; E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8 | 0.581 |
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