| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DDX10 | SETBP1 | ENSP00000314348 | ENSP00000282030 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10; Putative ATP-dependent RNA helicase | SET binding protein 1 | 0.632 |
| DDX10 | WHSC1L1 | ENSP00000314348 | ENSP00000313983 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10; Putative ATP-dependent RNA helicase | Wolf-Hirschhorn syndrome candidate 1-like 1 | 0.640 |
| EPHA4 | FUT2 | ENSP00000281821 | ENSP00000375748 | EPH receptor A4; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activa [...] | fucosyltransferase 2 (secretor status included); Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values | 0.581 |
| EPHA4 | SETBP1 | ENSP00000281821 | ENSP00000282030 | EPH receptor A4; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activa [...] | SET binding protein 1 | 0.642 |
| FUT2 | EPHA4 | ENSP00000375748 | ENSP00000281821 | fucosyltransferase 2 (secretor status included); Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values | EPH receptor A4; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activa [...] | 0.581 |
| FUT2 | SETBP1 | ENSP00000375748 | ENSP00000282030 | fucosyltransferase 2 (secretor status included); Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values | SET binding protein 1 | 0.728 |
| LMO2 | MECOM | ENSP00000257818 | ENSP00000264674 | LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state | MDS1 and EVI1 complex locus | 0.642 |
| LMO2 | PRDM16 | ENSP00000257818 | ENSP00000270722 | LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state | PR domain containing 16; Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation | 0.613 |
| LMO2 | SETBP1 | ENSP00000257818 | ENSP00000282030 | LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state | SET binding protein 1 | 0.684 |
| MECOM | LMO2 | ENSP00000264674 | ENSP00000257818 | MDS1 and EVI1 complex locus | LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state | 0.642 |
| MECOM | SETBP1 | ENSP00000264674 | ENSP00000282030 | MDS1 and EVI1 complex locus | SET binding protein 1 | 0.825 |
| PRDM16 | LMO2 | ENSP00000270722 | ENSP00000257818 | PR domain containing 16; Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation | LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state | 0.613 |
| PRDM16 | SETBP1 | ENSP00000270722 | ENSP00000282030 | PR domain containing 16; Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation | SET binding protein 1 | 0.893 |
| SET | SETBP1 | ENSP00000361777 | ENSP00000282030 | SET nuclear oncogene; Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T- lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibilit [...] | SET binding protein 1 | 0.826 |
| SETBP1 | DDX10 | ENSP00000282030 | ENSP00000314348 | SET binding protein 1 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10; Putative ATP-dependent RNA helicase | 0.632 |
| SETBP1 | EPHA4 | ENSP00000282030 | ENSP00000281821 | SET binding protein 1 | EPH receptor A4; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activa [...] | 0.642 |
| SETBP1 | FUT2 | ENSP00000282030 | ENSP00000375748 | SET binding protein 1 | fucosyltransferase 2 (secretor status included); Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values | 0.728 |
| SETBP1 | LMO2 | ENSP00000282030 | ENSP00000257818 | SET binding protein 1 | LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state | 0.684 |
| SETBP1 | MECOM | ENSP00000282030 | ENSP00000264674 | SET binding protein 1 | MDS1 and EVI1 complex locus | 0.825 |
| SETBP1 | PRDM16 | ENSP00000282030 | ENSP00000270722 | SET binding protein 1 | PR domain containing 16; Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation | 0.893 |
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