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STRINGSTRING
RAB39A RAB39A WDR53 WDR53 CCDC84 CCDC84 CWF19L2 CWF19L2 CDC5L CDC5L EFTUD2 EFTUD2 BUD31 BUD31 PRPF19 PRPF19 CDC40 CDC40 GJA8 GJA8 EEF2 EEF2
"CWF19L2" - CWF19-like 2, cell cycle control (S. pombe) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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white nodes:
second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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co-expression
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protein homology
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[Homology]
Score
CWF19L2CWF19-like 2, cell cycle control (S. pombe) (894 aa)    
Predicted Functional Partners:
CDC5L
CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (802 aa)
      score_image score_image       0.953
BUD31
BUD31 homolog (S. cerevisiae) (144 aa)
      score_image score_image       0.832
CDC40
cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing (579 aa)
      score_image score_image       0.810
PRPF19
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] (504 aa)
        score_image       0.723
WDR53
WD repeat domain 53 (358 aa)
            score_image   0.585
GJA8
gap junction protein, alpha 8, 50kDa (433 aa)
            score_image   0.539
EFTUD2
elongation factor Tu GTP binding domain containing 2; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP (972 aa)
        score_image       0.497
EEF2
eukaryotic translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (858 aa)
        score_image       0.497
CCDC84
coiled-coil domain containing 84 (332 aa)
            score_image   0.472
RAB39A
RAB39A, member RAS oncogene family; Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes (217 aa)
            score_image   0.459
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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