node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BUD31 | CDC40 | ENSP00000222969 | ENSP00000304370 | BUD31 homolog (S. cerevisiae) | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | 0.959 |
BUD31 | CDC5L | ENSP00000222969 | ENSP00000360532 | BUD31 homolog (S. cerevisiae) | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.978 |
BUD31 | CWF19L2 | ENSP00000222969 | ENSP00000282251 | BUD31 homolog (S. cerevisiae) | CWF19-like 2, cell cycle control (S. pombe) | 0.832 |
BUD31 | EEF2 | ENSP00000222969 | ENSP00000307940 | BUD31 homolog (S. cerevisiae) | eukaryotic translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome | 0.829 |
BUD31 | EFTUD2 | ENSP00000222969 | ENSP00000392094 | BUD31 homolog (S. cerevisiae) | elongation factor Tu GTP binding domain containing 2; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP | 0.853 |
BUD31 | PRPF19 | ENSP00000222969 | ENSP00000227524 | BUD31 homolog (S. cerevisiae) | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.980 |
CCDC84 | CWF19L2 | ENSP00000334767 | ENSP00000282251 | coiled-coil domain containing 84 | CWF19-like 2, cell cycle control (S. pombe) | 0.472 |
CDC40 | BUD31 | ENSP00000304370 | ENSP00000222969 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | BUD31 homolog (S. cerevisiae) | 0.959 |
CDC40 | CDC5L | ENSP00000304370 | ENSP00000360532 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.983 |
CDC40 | CWF19L2 | ENSP00000304370 | ENSP00000282251 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | CWF19-like 2, cell cycle control (S. pombe) | 0.810 |
CDC40 | EEF2 | ENSP00000304370 | ENSP00000307940 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | eukaryotic translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome | 0.845 |
CDC40 | EFTUD2 | ENSP00000304370 | ENSP00000392094 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | elongation factor Tu GTP binding domain containing 2; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP | 0.987 |
CDC40 | PRPF19 | ENSP00000304370 | ENSP00000227524 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.998 |
CDC5L | BUD31 | ENSP00000360532 | ENSP00000222969 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | BUD31 homolog (S. cerevisiae) | 0.978 |
CDC5L | CDC40 | ENSP00000360532 | ENSP00000304370 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | 0.983 |
CDC5L | CWF19L2 | ENSP00000360532 | ENSP00000282251 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | CWF19-like 2, cell cycle control (S. pombe) | 0.953 |
CDC5L | EEF2 | ENSP00000360532 | ENSP00000307940 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | eukaryotic translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome | 0.845 |
CDC5L | EFTUD2 | ENSP00000360532 | ENSP00000392094 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | elongation factor Tu GTP binding domain containing 2; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP | 0.961 |
CDC5L | PRPF19 | ENSP00000360532 | ENSP00000227524 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.999 |
CWF19L2 | BUD31 | ENSP00000282251 | ENSP00000222969 | CWF19-like 2, cell cycle control (S. pombe) | BUD31 homolog (S. cerevisiae) | 0.832 |