ZSCAN1 protein (Homo sapiens) - STRING network view

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ZSCAN1

zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation (408 aa)

Predicted Functional Partners:

ADAMTS3

0.801

ADAMTS4

0.800

GGH

0.681

GATA1

0.670

PLVAP

0.661

MYB

0.628

GATA2

0.614

PKD2

0.609

EIF2AK1

0.607

XRN1

0.543

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS3	ZSCAN1	ENSP00000286657	ENSP00000282326	ADAM metallopeptidase with thrombospondin type 1 motif, 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	0.801
ADAMTS4	ZSCAN1	ENSP00000356975	ENSP00000282326	ADAM metallopeptidase with thrombospondin type 1 motif, 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the ’392-Glu-\|-Ala-393’ site	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	0.800
EIF2AK1	ZSCAN1	ENSP00000199389	ENSP00000282326	eukaryotic translation initiation factor 2-alpha kinase 1	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	0.607
GATA1	MYB	ENSP00000365858	ENSP00000339992	GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells	v-myb myeloblastosis viral oncogene homolog (avian)	0.984
GATA1	ZSCAN1	ENSP00000365858	ENSP00000282326	GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	0.670
GATA2	MYB	ENSP00000345681	ENSP00000339992	GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5’-AGATAG-3’	v-myb myeloblastosis viral oncogene homolog (avian)	0.796
GATA2	ZSCAN1	ENSP00000345681	ENSP00000282326	GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5’-AGATAG-3’	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	0.614
GGH	ZSCAN1	ENSP00000260118	ENSP00000282326	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	0.681
MYB	GATA1	ENSP00000339992	ENSP00000365858	v-myb myeloblastosis viral oncogene homolog (avian)	GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells	0.984
MYB	GATA2	ENSP00000339992	ENSP00000345681	v-myb myeloblastosis viral oncogene homolog (avian)	GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5’-AGATAG-3’	0.796
MYB	ZSCAN1	ENSP00000339992	ENSP00000282326	v-myb myeloblastosis viral oncogene homolog (avian)	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	0.628
PKD2	ZSCAN1	ENSP00000237596	ENSP00000282326	polycystic kidney disease 2 (autosomal dominant); Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis (By similarity). Acts as a regulator of cilium length, together with PKD1 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intrac [...]	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	0.609
PLVAP	ZSCAN1	ENSP00000252590	ENSP00000282326	plasmalemma vesicle associated protein; Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	0.661
XRN1	ZSCAN1	ENSP00000264951	ENSP00000282326	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	0.543
ZSCAN1	ADAMTS3	ENSP00000282326	ENSP00000286657	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	ADAM metallopeptidase with thrombospondin type 1 motif, 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens	0.801
ZSCAN1	ADAMTS4	ENSP00000282326	ENSP00000356975	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	ADAM metallopeptidase with thrombospondin type 1 motif, 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the ’392-Glu-\|-Ala-393’ site	0.800
ZSCAN1	EIF2AK1	ENSP00000282326	ENSP00000199389	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	eukaryotic translation initiation factor 2-alpha kinase 1	0.607
ZSCAN1	GATA1	ENSP00000282326	ENSP00000365858	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells	0.670
ZSCAN1	GATA2	ENSP00000282326	ENSP00000345681	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5’-AGATAG-3’	0.614
ZSCAN1	GGH	ENSP00000282326	ENSP00000260118	zinc finger and SCAN domain containing 1; May be involved in transcriptional regulation	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates	0.681

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