| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ERGIC1 | TIRAP3 | ENSP00000377374 | ENSP00000282382 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | TMED7-TICAM2 readthrough | 0.607 |
| FEM1A | SEMA6B | ENSP00000269856 | ENSP00000301293 | fem-1 homolog a (C. elegans); Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4 | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; May play a role in both peripheral and central nervous system development (By similarity) | 0.585 |
| FEM1A | TIRAP3 | ENSP00000269856 | ENSP00000282382 | fem-1 homolog a (C. elegans); Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4 | TMED7-TICAM2 readthrough | 0.594 |
| FEM1C | SEMA6B | ENSP00000274457 | ENSP00000301293 | fem-1 homolog c (C. elegans); Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity) | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; May play a role in both peripheral and central nervous system development (By similarity) | 0.585 |
| FEM1C | TIRAP3 | ENSP00000274457 | ENSP00000282382 | fem-1 homolog c (C. elegans); Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity) | TMED7-TICAM2 readthrough | 0.594 |
| IL1R1 | IL1RAP | ENSP00000233946 | ENSP00000314807 | interleukin 1 receptor, type I; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex | interleukin 1 receptor accessory protein; Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular [...] | 0.999 |
| IL1R1 | TIRAP3 | ENSP00000233946 | ENSP00000282382 | interleukin 1 receptor, type I; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex | TMED7-TICAM2 readthrough | 0.551 |
| IL1R1 | TLR4 | ENSP00000233946 | ENSP00000363089 | interleukin 1 receptor, type I; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex | toll-like receptor 4 | 0.562 |
| IL1R1 | TRAF6 | ENSP00000233946 | ENSP00000337853 | interleukin 1 receptor, type I; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex | TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...] | 0.999 |
| IL1RAP | IL1R1 | ENSP00000314807 | ENSP00000233946 | interleukin 1 receptor accessory protein; Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular [...] | interleukin 1 receptor, type I; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex | 0.999 |
| IL1RAP | TIRAP | ENSP00000314807 | ENSP00000376445 | interleukin 1 receptor accessory protein; Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular [...] | toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6 | 0.750 |
| IL1RAP | TIRAP3 | ENSP00000314807 | ENSP00000282382 | interleukin 1 receptor accessory protein; Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular [...] | TMED7-TICAM2 readthrough | 0.551 |
| IL1RAP | TRAF6 | ENSP00000314807 | ENSP00000337853 | interleukin 1 receptor accessory protein; Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular [...] | TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...] | 0.971 |
| SEMA6B | FEM1A | ENSP00000301293 | ENSP00000269856 | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; May play a role in both peripheral and central nervous system development (By similarity) | fem-1 homolog a (C. elegans); Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4 | 0.585 |
| SEMA6B | FEM1C | ENSP00000301293 | ENSP00000274457 | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; May play a role in both peripheral and central nervous system development (By similarity) | fem-1 homolog c (C. elegans); Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity) | 0.585 |
| SEMA6B | TIRAP3 | ENSP00000301293 | ENSP00000282382 | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; May play a role in both peripheral and central nervous system development (By similarity) | TMED7-TICAM2 readthrough | 0.587 |
| TICAM1 | TIRAP | ENSP00000248244 | ENSP00000376445 | toll-like receptor adaptor molecule 1; Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively | toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6 | 0.842 |
| TICAM1 | TIRAP3 | ENSP00000248244 | ENSP00000282382 | toll-like receptor adaptor molecule 1; Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively | TMED7-TICAM2 readthrough | 0.642 |
| TICAM1 | TLR4 | ENSP00000248244 | ENSP00000363089 | toll-like receptor adaptor molecule 1; Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively | toll-like receptor 4 | 0.999 |
| TICAM1 | TRAF6 | ENSP00000248244 | ENSP00000337853 | toll-like receptor adaptor molecule 1; Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively | TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...] | 0.999 |
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