node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DHDDS | ENSG00000254673 | ENSP00000353104 | ENSP00000435061 | dehydrodolichyl diphosphate synthase | Uncharacterized protein | 0.900 |
DHDDS | FDFT1 | ENSP00000353104 | ENSP00000220584 | dehydrodolichyl diphosphate synthase | farnesyl-diphosphate farnesyltransferase 1 | 0.804 |
DHDDS | FDPS | ENSP00000353104 | ENSP00000349078 | dehydrodolichyl diphosphate synthase | farnesyl diphosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate | 0.956 |
DHDDS | FNTB | ENSP00000353104 | ENSP00000246166 | dehydrodolichyl diphosphate synthase | farnesyltransferase, CAAX box, beta; Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding | 0.900 |
DHDDS | GGPS1 | ENSP00000353104 | ENSP00000282841 | dehydrodolichyl diphosphate synthase | geranylgeranyl diphosphate synthase 1; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins | 0.930 |
DHDDS | MVD | ENSP00000353104 | ENSP00000301012 | dehydrodolichyl diphosphate synthase | mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes | 0.912 |
DHDDS | PDSS1 | ENSP00000353104 | ENSP00000365388 | dehydrodolichyl diphosphate synthase | prenyl (decaprenyl) diphosphate synthase, subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10 | 0.933 |
ENSG00000254673 | DHDDS | ENSP00000435061 | ENSP00000353104 | Uncharacterized protein | dehydrodolichyl diphosphate synthase | 0.900 |
ENSG00000254673 | FDFT1 | ENSP00000435061 | ENSP00000220584 | Uncharacterized protein | farnesyl-diphosphate farnesyltransferase 1 | 0.810 |
ENSG00000254673 | FDPS | ENSP00000435061 | ENSP00000349078 | Uncharacterized protein | farnesyl diphosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate | 0.907 |
ENSG00000254673 | FNTB | ENSP00000435061 | ENSP00000246166 | Uncharacterized protein | farnesyltransferase, CAAX box, beta; Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding | 0.974 |
ENSG00000254673 | GGPS1 | ENSP00000435061 | ENSP00000282841 | Uncharacterized protein | geranylgeranyl diphosphate synthase 1; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins | 0.907 |
ENSG00000254673 | PDSS1 | ENSP00000435061 | ENSP00000365388 | Uncharacterized protein | prenyl (decaprenyl) diphosphate synthase, subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10 | 0.907 |
FDFT1 | DHDDS | ENSP00000220584 | ENSP00000353104 | farnesyl-diphosphate farnesyltransferase 1 | dehydrodolichyl diphosphate synthase | 0.804 |
FDFT1 | ENSG00000254673 | ENSP00000220584 | ENSP00000435061 | farnesyl-diphosphate farnesyltransferase 1 | Uncharacterized protein | 0.810 |
FDFT1 | FDPS | ENSP00000220584 | ENSP00000349078 | farnesyl-diphosphate farnesyltransferase 1 | farnesyl diphosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate | 0.985 |
FDFT1 | FNTB | ENSP00000220584 | ENSP00000246166 | farnesyl-diphosphate farnesyltransferase 1 | farnesyltransferase, CAAX box, beta; Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding | 0.864 |
FDFT1 | GGPS1 | ENSP00000220584 | ENSP00000282841 | farnesyl-diphosphate farnesyltransferase 1 | geranylgeranyl diphosphate synthase 1; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins | 0.945 |
FDFT1 | IDI1 | ENSP00000220584 | ENSP00000370748 | farnesyl-diphosphate farnesyltransferase 1 | isopentenyl-diphosphate delta isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.848 |
FDFT1 | IDI2 | ENSP00000220584 | ENSP00000277517 | farnesyl-diphosphate farnesyltransferase 1 | isopentenyl-diphosphate delta isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.654 |