node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS18 | COL15A1 | ENSP00000282849 | ENSP00000364140 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle | 0.781 |
ADAMTS18 | COL18A1 | ENSP00000282849 | ENSP00000347665 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | collagen, type XVIII, alpha 1 | 0.872 |
ADAMTS18 | ENPEP | ENSP00000282849 | ENSP00000265162 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells | 0.451 |
ADAMTS18 | FLJ42280 | ENSP00000282849 | ENSP00000349114 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | chromosome 7 open reading frame 76 | 0.457 |
ADAMTS18 | MYO1D | ENSP00000282849 | ENSP00000324527 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | myosin ID; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | 0.750 |
ADAMTS18 | PI15 | ENSP00000282849 | ENSP00000260113 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin | 0.468 |
ADAMTS18 | RAB11FIP4 | ENSP00000282849 | ENSP00000312837 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | RAB11 family interacting protein 4 (class II); Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an ’address tag’ delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6 | 0.680 |
ADAMTS18 | TGFBR3 | ENSP00000282849 | ENSP00000212355 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | transforming growth factor, beta receptor III; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors | 0.537 |
ADAMTS18 | UNC119 | ENSP00000282849 | ENSP00000337040 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | unc-119 homolog (C. elegans); Myristoyl-binding protein that acts as a cargo adapter- specifically binds the myristoyl moiety of a subset of N- terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G- protein localization and trafficking in sensory neurons. Binds myristoylated NPHP3; however, in contrast to UNC119B, does not seem to play a major role in ciliary membrane localization of NPHP3. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells | 0.659 |
COL15A1 | ADAMTS18 | ENSP00000364140 | ENSP00000282849 | collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | 0.781 |
COL15A1 | COL18A1 | ENSP00000364140 | ENSP00000347665 | collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle | collagen, type XVIII, alpha 1 | 0.930 |
COL18A1 | ADAMTS18 | ENSP00000347665 | ENSP00000282849 | collagen, type XVIII, alpha 1 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | 0.872 |
COL18A1 | COL15A1 | ENSP00000347665 | ENSP00000364140 | collagen, type XVIII, alpha 1 | collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle | 0.930 |
ENPEP | ADAMTS18 | ENSP00000265162 | ENSP00000282849 | glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | 0.451 |
ENPEP | PI15 | ENSP00000265162 | ENSP00000260113 | glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells | peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin | 0.575 |
FLJ42280 | ADAMTS18 | ENSP00000349114 | ENSP00000282849 | chromosome 7 open reading frame 76 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | 0.457 |
MYO1D | ADAMTS18 | ENSP00000324527 | ENSP00000282849 | myosin ID; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | 0.750 |
MYO1D | RAB11FIP4 | ENSP00000324527 | ENSP00000312837 | myosin ID; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | RAB11 family interacting protein 4 (class II); Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an ’address tag’ delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6 | 0.751 |
MYO1D | UNC119 | ENSP00000324527 | ENSP00000337040 | myosin ID; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | unc-119 homolog (C. elegans); Myristoyl-binding protein that acts as a cargo adapter- specifically binds the myristoyl moiety of a subset of N- terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G- protein localization and trafficking in sensory neurons. Binds myristoylated NPHP3; however, in contrast to UNC119B, does not seem to play a major role in ciliary membrane localization of NPHP3. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells | 0.749 |
PI15 | ADAMTS18 | ENSP00000260113 | ENSP00000282849 | peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | 0.468 |