| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AK1 | ZNF117 | ENSP00000362249 | ENSP00000282869 | adenylate kinase 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | zinc finger protein 117; May be involved in transcriptional regulation | 0.529 |
| ECD | ZNF117 | ENSP00000401566 | ENSP00000282869 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | zinc finger protein 117; May be involved in transcriptional regulation | 0.577 |
| FBXL19 | UTY | ENSP00000369666 | ENSP00000328939 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | 0.615 |
| FBXL19 | ZNF117 | ENSP00000369666 | ENSP00000282869 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 117; May be involved in transcriptional regulation | 0.501 |
| KDM2A | UTY | ENSP00000432786 | ENSP00000328939 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | 0.615 |
| KDM2A | ZNF117 | ENSP00000432786 | ENSP00000282869 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 117; May be involved in transcriptional regulation | 0.501 |
| KDM2B | UTY | ENSP00000366271 | ENSP00000328939 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | 0.615 |
| KDM2B | ZNF117 | ENSP00000366271 | ENSP00000282869 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 117; May be involved in transcriptional regulation | 0.501 |
| PTPN23 | ZNF117 | ENSP00000265562 | ENSP00000282869 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 117; May be involved in transcriptional regulation | 0.476 |
| SS18 | ZNF117 | ENSP00000414516 | ENSP00000282869 | synovial sarcoma translocation, chromosome 18; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation | zinc finger protein 117; May be involved in transcriptional regulation | 0.801 |
| STAG3L3 | ZNF117 | ENSP00000312329 | ENSP00000282869 | stromal antigen 3-like 3 | zinc finger protein 117; May be involved in transcriptional regulation | 0.515 |
| UTY | FBXL19 | ENSP00000328939 | ENSP00000369666 | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.615 |
| UTY | KDM2A | ENSP00000328939 | ENSP00000432786 | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.615 |
| UTY | KDM2B | ENSP00000328939 | ENSP00000366271 | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.615 |
| UTY | ZNF117 | ENSP00000328939 | ENSP00000282869 | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | zinc finger protein 117; May be involved in transcriptional regulation | 0.483 |
| XRN1 | ZNF117 | ENSP00000264951 | ENSP00000282869 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 117; May be involved in transcriptional regulation | 0.543 |
| ZNF117 | AK1 | ENSP00000282869 | ENSP00000362249 | zinc finger protein 117; May be involved in transcriptional regulation | adenylate kinase 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | 0.529 |
| ZNF117 | ECD | ENSP00000282869 | ENSP00000401566 | zinc finger protein 117; May be involved in transcriptional regulation | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | 0.577 |
| ZNF117 | FBXL19 | ENSP00000282869 | ENSP00000369666 | zinc finger protein 117; May be involved in transcriptional regulation | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
| ZNF117 | KDM2A | ENSP00000282869 | ENSP00000432786 | zinc finger protein 117; May be involved in transcriptional regulation | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
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