node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CELA3A | CPB1 | ENSP00000290122 | ENSP00000282957 | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity | carboxypeptidase B1 (tissue) | 0.598 |
CELA3A | CTRB1 | ENSP00000290122 | ENSP00000354294 | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity | chymotrypsinogen B1 | 0.429 |
CELA3B | CPB1 | ENSP00000338369 | ENSP00000282957 | chymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity | carboxypeptidase B1 (tissue) | 0.602 |
CELA3B | CTRB1 | ENSP00000338369 | ENSP00000354294 | chymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity | chymotrypsinogen B1 | 0.424 |
CPB1 | CELA3A | ENSP00000282957 | ENSP00000290122 | carboxypeptidase B1 (tissue) | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity | 0.598 |
CPB1 | CELA3B | ENSP00000282957 | ENSP00000338369 | carboxypeptidase B1 (tissue) | chymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity | 0.602 |
CPB1 | CPE | ENSP00000282957 | ENSP00000386104 | carboxypeptidase B1 (tissue) | carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin | 0.781 |
CPB1 | CPN1 | ENSP00000282957 | ENSP00000359446 | carboxypeptidase B1 (tissue) | carboxypeptidase N, polypeptide 1; Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation | 0.583 |
CPB1 | CPN2 | ENSP00000282957 | ENSP00000319464 | carboxypeptidase B1 (tissue) | carboxypeptidase N, polypeptide 2; The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit | 0.742 |
CPB1 | CTRB1 | ENSP00000282957 | ENSP00000354294 | carboxypeptidase B1 (tissue) | chymotrypsinogen B1 | 0.584 |
CPB1 | ENPP4 | ENSP00000282957 | ENSP00000318066 | carboxypeptidase B1 (tissue) | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative); Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors | 0.586 |
CPB1 | PION | ENSP00000282957 | ENSP00000257626 | carboxypeptidase B1 (tissue) | pigeon homolog (Drosophila); Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta- [...] | 0.607 |
CPB1 | PLGRKT | ENSP00000282957 | ENSP00000223864 | carboxypeptidase B1 (tissue) | plasminogen receptor, C-terminal lysine transmembrane protein; Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9 | 0.636 |
CPB1 | PSMA6 | ENSP00000282957 | ENSP00000261479 | carboxypeptidase B1 (tissue) | proteasome (prosome, macropain) subunit, alpha type, 6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity) | 0.593 |
CPE | CPB1 | ENSP00000386104 | ENSP00000282957 | carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin | carboxypeptidase B1 (tissue) | 0.781 |
CPE | PSMA6 | ENSP00000386104 | ENSP00000261479 | carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin | proteasome (prosome, macropain) subunit, alpha type, 6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity) | 0.764 |
CPN1 | CPB1 | ENSP00000359446 | ENSP00000282957 | carboxypeptidase N, polypeptide 1; Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation | carboxypeptidase B1 (tissue) | 0.583 |
CPN1 | CPN2 | ENSP00000359446 | ENSP00000319464 | carboxypeptidase N, polypeptide 1; Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation | carboxypeptidase N, polypeptide 2; The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit | 0.938 |
CPN2 | CPB1 | ENSP00000319464 | ENSP00000282957 | carboxypeptidase N, polypeptide 2; The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit | carboxypeptidase B1 (tissue) | 0.742 |
CPN2 | CPN1 | ENSP00000319464 | ENSP00000359446 | carboxypeptidase N, polypeptide 2; The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit | carboxypeptidase N, polypeptide 1; Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation | 0.938 |