RIOK2 protein (Homo sapiens) - STRING network view

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Score

RIOK2

RIO kinase 2 (yeast) (552 aa)

Predicted Functional Partners:

TSR1

0.999

NOB1

0.995

PNO1

0.994

LTV1

0.991

BYSL

0.989

DIMT1

0.985

EIF2A

0.948

RRP12

0.942

TFB2M

0.942

KRR1

0.914

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BYSL	DIMT1	ENSP00000230340	ENSP00000199320	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity)	0.995
BYSL	KRR1	ENSP00000230340	ENSP00000229214	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	KRR1, small subunit (SSU) processome component, homolog (yeast); Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)	0.984
BYSL	LTV1	ENSP00000230340	ENSP00000356548	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	LTV1 homolog (S. cerevisiae)	0.998
BYSL	NOB1	ENSP00000230340	ENSP00000268802	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); May play a role in mRNA degradation	0.998
BYSL	PNO1	ENSP00000230340	ENSP00000263657	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	partner of NOB1 homolog (S. cerevisiae)	0.999
BYSL	RIOK2	ENSP00000230340	ENSP00000283109	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	RIO kinase 2 (yeast)	0.989
BYSL	RRP12	ENSP00000230340	ENSP00000360031	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	ribosomal RNA processing 12 homolog (S. cerevisiae)	0.998
BYSL	TFB2M	ENSP00000230340	ENSP00000355471	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	transcription factor B2, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity	0.983
BYSL	TSR1	ENSP00000230340	ENSP00000301364	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.999
DIMT1	BYSL	ENSP00000199320	ENSP00000230340	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity)	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	0.995
DIMT1	KRR1	ENSP00000199320	ENSP00000229214	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity)	KRR1, small subunit (SSU) processome component, homolog (yeast); Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)	0.869
DIMT1	LTV1	ENSP00000199320	ENSP00000356548	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity)	LTV1 homolog (S. cerevisiae)	0.945
DIMT1	NOB1	ENSP00000199320	ENSP00000268802	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity)	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); May play a role in mRNA degradation	0.762
DIMT1	PNO1	ENSP00000199320	ENSP00000263657	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity)	partner of NOB1 homolog (S. cerevisiae)	0.990
DIMT1	RIOK2	ENSP00000199320	ENSP00000283109	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity)	RIO kinase 2 (yeast)	0.985
DIMT1	RRP12	ENSP00000199320	ENSP00000360031	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity)	ribosomal RNA processing 12 homolog (S. cerevisiae)	0.962
DIMT1	TSR1	ENSP00000199320	ENSP00000301364	DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity)	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.988
EIF2A	RIOK2	ENSP00000417229	ENSP00000283109	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	RIO kinase 2 (yeast)	0.948
EIF2A	TSR1	ENSP00000417229	ENSP00000301364	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.885
KRR1	BYSL	ENSP00000229214	ENSP00000230340	KRR1, small subunit (SSU) processome component, homolog (yeast); Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)	bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos	0.984

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