| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAM81B | HYDIN | ENSP00000283357 | ENSP00000314736 | family with sequence similarity 81, member B | HYDIN, axonemal central pair apparatus protein | 0.561 |
| FAM81B | KCNJ12 | ENSP00000283357 | ENSP00000328150 | family with sequence similarity 81, member B | potassium inwardly-rectifying channel, subfamily J, member 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracell [...] | 0.450 |
| FAM81B | MTRNR2L1 | ENSP00000283357 | ENSP00000439228 | family with sequence similarity 81, member B | MT-RNR2-like 1; Plays a role as a neuroprotective and antiapoptotic factor (By similarity) | 0.807 |
| FAM81B | RBCK1 | ENSP00000283357 | ENSP00000348632 | family with sequence similarity 81, member B | RanBP-type and C3HC4-type zinc finger containing 1; E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear (’M-1’-linked) polyubiquitin chains to substrates and plays a key role in NF- kappa-B activation and regulation of inflammation. LUBA [...] | 0.407 |
| FAM81B | RINT1 | ENSP00000283357 | ENSP00000257700 | family with sequence similarity 81, member B | RAD50 interactor 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control | 0.551 |
| FAM81B | TAF1L | ENSP00000283357 | ENSP00000418379 | family with sequence similarity 81, member B | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced | 0.588 |
| HYDIN | FAM81B | ENSP00000314736 | ENSP00000283357 | HYDIN, axonemal central pair apparatus protein | family with sequence similarity 81, member B | 0.561 |
| HYDIN | MTRNR2L1 | ENSP00000314736 | ENSP00000439228 | HYDIN, axonemal central pair apparatus protein | MT-RNR2-like 1; Plays a role as a neuroprotective and antiapoptotic factor (By similarity) | 0.461 |
| KCNJ12 | FAM81B | ENSP00000328150 | ENSP00000283357 | potassium inwardly-rectifying channel, subfamily J, member 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracell [...] | family with sequence similarity 81, member B | 0.450 |
| KCNJ12 | MTRNR2L1 | ENSP00000328150 | ENSP00000439228 | potassium inwardly-rectifying channel, subfamily J, member 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracell [...] | MT-RNR2-like 1; Plays a role as a neuroprotective and antiapoptotic factor (By similarity) | 0.499 |
| MTRNR2L1 | FAM81B | ENSP00000439228 | ENSP00000283357 | MT-RNR2-like 1; Plays a role as a neuroprotective and antiapoptotic factor (By similarity) | family with sequence similarity 81, member B | 0.807 |
| MTRNR2L1 | HYDIN | ENSP00000439228 | ENSP00000314736 | MT-RNR2-like 1; Plays a role as a neuroprotective and antiapoptotic factor (By similarity) | HYDIN, axonemal central pair apparatus protein | 0.461 |
| MTRNR2L1 | KCNJ12 | ENSP00000439228 | ENSP00000328150 | MT-RNR2-like 1; Plays a role as a neuroprotective and antiapoptotic factor (By similarity) | potassium inwardly-rectifying channel, subfamily J, member 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracell [...] | 0.499 |
| MTRNR2L1 | TAF1L | ENSP00000439228 | ENSP00000418379 | MT-RNR2-like 1; Plays a role as a neuroprotective and antiapoptotic factor (By similarity) | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced | 0.508 |
| RBCK1 | FAM81B | ENSP00000348632 | ENSP00000283357 | RanBP-type and C3HC4-type zinc finger containing 1; E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear (’M-1’-linked) polyubiquitin chains to substrates and plays a key role in NF- kappa-B activation and regulation of inflammation. LUBA [...] | family with sequence similarity 81, member B | 0.407 |
| RINT1 | FAM81B | ENSP00000257700 | ENSP00000283357 | RAD50 interactor 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control | family with sequence similarity 81, member B | 0.551 |
| TAF1L | FAM81B | ENSP00000418379 | ENSP00000283357 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced | family with sequence similarity 81, member B | 0.588 |
| TAF1L | MTRNR2L1 | ENSP00000418379 | ENSP00000439228 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced | MT-RNR2-like 1; Plays a role as a neuroprotective and antiapoptotic factor (By similarity) | 0.508 |
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