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STRINGSTRING
ESRRG ESRRG CYP11A1 CYP11A1 TFCP2L1 TFCP2L1 ESRRB ESRRB RNF2 RNF2 YY1 YY1 UBP1 UBP1 WWP2 WWP2 WDR4 WDR4 TRIM28 TRIM28 SGPP1 SGPP1
"UBP1" - upstream binding protein 1 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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UBP1upstream binding protein 1 (LBP-1a); Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box (540 aa)    
Predicted Functional Partners:
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1; Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone (521 aa)
             score_image   0.918
YY1
YY1 transcription factor; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5’-CCGCCATNTT-3’; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repre [...] (414 aa)
             score_image   0.876
SGPP1
sphingosine-1-phosphate phosphatase 1; Has enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels (441 aa)
             score_image   0.744
RNF2
ring finger protein 2; E3 ubiquitin-protein ligase that mediates monoubiquitination of ’Lys-119’ of histone H2A, thereby playing a central role in histone code and gene regulation. H2A ’Lys-119’ ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includ [...] (336 aa)
             score_image   0.695
TRIM28
tripartite motif containing 28; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitm [...] (835 aa)
         score_image   score_image   0.644
WDR4
WD repeat domain 4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit (412 aa)
         score_image       0.644
ESRRB
estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity (508 aa)
             score_image   0.587
ESRRG
estrogen-related receptor gamma (458 aa)
             score_image   0.587
TFCP2L1
transcription factor CP2-like 1; Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1 (479 aa)
         score_image   score_image score_image 0.585
WWP2
WW domain containing E3 ubiquitin protein ligase 2 (870 aa)
         score_image       0.570
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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