| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMC8 | GID8 | ENSP00000420333 | ENSP00000266069 | armadillo repeat containing 8 | GID complex subunit 8 homolog (S. cerevisiae) | 0.980 |
| ARMC8 | MAEA | ENSP00000420333 | ENSP00000302830 | armadillo repeat containing 8 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.938 |
| ARMC8 | RANBP10 | ENSP00000420333 | ENSP00000316589 | armadillo repeat containing 8 | RAN binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] | 0.582 |
| ARMC8 | RANBP9 | ENSP00000420333 | ENSP00000011619 | armadillo repeat containing 8 | RAN binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] | 0.630 |
| ARMC8 | RMND5A | ENSP00000420333 | ENSP00000283632 | armadillo repeat containing 8 | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.925 |
| ARMC8 | WDR26 | ENSP00000420333 | ENSP00000408108 | armadillo repeat containing 8 | WD repeat domain 26; May be involved in MAPK pathways | 0.859 |
| C21orf2 | MAEA | ENSP00000344566 | ENSP00000302830 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.869 |
| C21orf2 | RMND5A | ENSP00000344566 | ENSP00000283632 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.778 |
| GID8 | ARMC8 | ENSP00000266069 | ENSP00000420333 | GID complex subunit 8 homolog (S. cerevisiae) | armadillo repeat containing 8 | 0.980 |
| GID8 | MAEA | ENSP00000266069 | ENSP00000302830 | GID complex subunit 8 homolog (S. cerevisiae) | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.978 |
| GID8 | MKLN1 | ENSP00000266069 | ENSP00000323527 | GID complex subunit 8 homolog (S. cerevisiae) | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | 0.941 |
| GID8 | PAFAH1B1 | ENSP00000266069 | ENSP00000380378 | GID complex subunit 8 homolog (S. cerevisiae) | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] | 0.572 |
| GID8 | RANBP10 | ENSP00000266069 | ENSP00000316589 | GID complex subunit 8 homolog (S. cerevisiae) | RAN binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] | 0.772 |
| GID8 | RANBP9 | ENSP00000266069 | ENSP00000011619 | GID complex subunit 8 homolog (S. cerevisiae) | RAN binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] | 0.976 |
| GID8 | RMND5A | ENSP00000266069 | ENSP00000283632 | GID complex subunit 8 homolog (S. cerevisiae) | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.992 |
| GID8 | WDR26 | ENSP00000266069 | ENSP00000408108 | GID complex subunit 8 homolog (S. cerevisiae) | WD repeat domain 26; May be involved in MAPK pathways | 0.980 |
| MAEA | ARMC8 | ENSP00000302830 | ENSP00000420333 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | armadillo repeat containing 8 | 0.938 |
| MAEA | C21orf2 | ENSP00000302830 | ENSP00000344566 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.869 |
| MAEA | GID8 | ENSP00000302830 | ENSP00000266069 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | GID complex subunit 8 homolog (S. cerevisiae) | 0.978 |
| MAEA | MKLN1 | ENSP00000302830 | ENSP00000323527 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | 0.571 |
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