Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
ABCB4 ABCB4 HSD3B7 HSD3B7 NR1H4 NR1H4 GGTLC2 GGTLC2 GGT1 GGT1 TMEM30B TMEM30B ABCB11 ABCB11 ATP8B1 ATP8B1 TMEM30C TMEM30C TMEM30A TMEM30A BACH2 BACH2
"ATP8B1" - ATPase, aminophospholipid transporter, class I, type 8B, member 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ATP8B1ATPase, aminophospholipid transporter, class I, type 8B, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both (1251 aa)    
Predicted Functional Partners:
TMEM30A
transmembrane protein 30A (361 aa)
        score_image   score_image   0.995
TMEM30B
transmembrane protein 30B (351 aa)
        score_image   score_image   0.943
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes (1321 aa)
        score_image   score_image   0.871
TMEM30C
transmembrane protein 30C (113 aa)
        score_image   score_image   0.763
ABCB4
ATP-binding cassette, sub-family B (MDR/TAP), member 4; Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte (1286 aa)
        score_image   score_image   0.758
NR1H4
nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus (486 aa)
            score_image   0.753
GGTLC2
gamma-glutamyltransferase light chain 2 (218 aa)
            score_image   0.753
HSD3B7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (369 aa)
            score_image   0.748
GGT1
gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive (569 aa)
            score_image   0.747
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2; Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity) (841 aa)
            score_image   0.741
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (34%)