| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C3orf35 | CTDSPL | ENSP00000331625 | ENSP00000273179 | chromosome 3 open reading frame 35 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; Preferentially catalyzes the dephosphorylation of ’Ser- 5’ within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells | 0.659 |
| C3orf35 | VILL | ENSP00000331625 | ENSP00000283713 | chromosome 3 open reading frame 35 | villin-like; Possible tumor suppressor | 0.581 |
| COX7A1 | VILL | ENSP00000292907 | ENSP00000283713 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle); This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | villin-like; Possible tumor suppressor | 0.584 |
| COX8A | VILL | ENSP00000321260 | ENSP00000283713 | cytochrome c oxidase subunit VIIIA (ubiquitous); This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | villin-like; Possible tumor suppressor | 0.506 |
| CTDSPL | C3orf35 | ENSP00000273179 | ENSP00000331625 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; Preferentially catalyzes the dephosphorylation of ’Ser- 5’ within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells | chromosome 3 open reading frame 35 | 0.659 |
| CTDSPL | VILL | ENSP00000273179 | ENSP00000283713 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; Preferentially catalyzes the dephosphorylation of ’Ser- 5’ within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells | villin-like; Possible tumor suppressor | 0.504 |
| ITGA2 | ITM2B | ENSP00000296585 | ENSP00000367828 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | integral membrane protein 2B; Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites | 0.643 |
| ITGA2 | LRRC15 | ENSP00000296585 | ENSP00000389128 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | leucine rich repeat containing 15 | 0.501 |
| ITGA2 | VILL | ENSP00000296585 | ENSP00000283713 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | villin-like; Possible tumor suppressor | 0.418 |
| ITGA2 | VWF | ENSP00000296585 | ENSP00000261405 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma | 0.858 |
| ITM2B | ITGA2 | ENSP00000367828 | ENSP00000296585 | integral membrane protein 2B; Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | 0.643 |
| ITM2B | LRRC15 | ENSP00000367828 | ENSP00000389128 | integral membrane protein 2B; Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites | leucine rich repeat containing 15 | 0.450 |
| ITM2B | VILL | ENSP00000367828 | ENSP00000283713 | integral membrane protein 2B; Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites | villin-like; Possible tumor suppressor | 0.672 |
| LRRC15 | ITGA2 | ENSP00000389128 | ENSP00000296585 | leucine rich repeat containing 15 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | 0.501 |
| LRRC15 | ITM2B | ENSP00000389128 | ENSP00000367828 | leucine rich repeat containing 15 | integral membrane protein 2B; Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites | 0.450 |
| LRRC15 | VILL | ENSP00000389128 | ENSP00000283713 | leucine rich repeat containing 15 | villin-like; Possible tumor suppressor | 0.416 |
| LRRC15 | VWF | ENSP00000389128 | ENSP00000261405 | leucine rich repeat containing 15 | von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma | 0.580 |
| TNK1 | VILL | ENSP00000312309 | ENSP00000283713 | tyrosine kinase, non-receptor, 1; Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction | villin-like; Possible tumor suppressor | 0.505 |
| VILL | C3orf35 | ENSP00000283713 | ENSP00000331625 | villin-like; Possible tumor suppressor | chromosome 3 open reading frame 35 | 0.581 |
| VILL | COX7A1 | ENSP00000283713 | ENSP00000292907 | villin-like; Possible tumor suppressor | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle); This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | 0.584 |
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