Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
|||||
 | HGD | homogentisate 1,2-dioxygenase (445 aa) | ||||||||||||
Predicted Functional Partners:
| ||||||||||||||
 | HPD | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine (393 aa) |
 |
|
|
|
0.997 | |||||||
 | GSTZ1 | glutathione S-transferase zeta 1 (216 aa) |
|
|
|
|
|
0.975 | ||||||
 | FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) (419 aa) |
|
|
|
|
0.896 | |||||||
 | HPDL | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) (371 aa) |
|
|
|
0.892 | ||||||||
 | SI | sucrase-isomaltase (alpha-glucosidase); Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides (1827 aa) |
|
0.750 | ||||||||||
 | TAT | tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine (454 aa) |
|
|
0.733 | |||||||||
 | PAH | phenylalanine hydroxylase (452 aa) |
|
|
|
0.668 | ||||||||
 | CTBP2 | C-terminal binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity) (985 aa) |
|
|
0.606 | |||||||||
 | CTBP1 | C-terminal binding protein 1; Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity (440 aa) |
|
|
0.605 | |||||||||
 | ALDH18A1 | aldehyde dehydrogenase 18 family, member A1 (795 aa) |
|
0.600 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
