node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKH | CHST12 | ENSP00000284268 | ENSP00000258711 | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | carbohydrate (chondroitin 4) sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor | 0.581 |
ANKH | CLCNKB | ENSP00000284268 | ENSP00000364831 | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | chloride channel, voltage-sensitive Kb; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms | 0.757 |
ANKH | CREB3L2 | ENSP00000284268 | ENSP00000329140 | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | cAMP responsive element binding protein 3-like 2; Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity) | 0.512 |
ANKH | ENPP1 | ENSP00000284268 | ENSP00000354238 | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | ectonucleotide pyrophosphatase/phosphodiesterase 1; By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. In vitro, has a broad specificity, hydrolyzing other nucleoside 5’ triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3’,5’-cAMP to AMP. May also be involved in the regu [...] | 0.550 |
ANKH | ESR1 | ENSP00000284268 | ENSP00000206249 | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | 0.470 |
ANKH | GHR | ENSP00000284268 | ENSP00000230882 | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity) | 0.610 |
ANKH | KDELR3 | ENSP00000284268 | ENSP00000386918 | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity) | 0.494 |
ANKH | LRCH1 | ENSP00000284268 | ENSP00000374447 | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.467 |
ANKH | MATN1 | ENSP00000284268 | ENSP00000362870 | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | matrilin 1, cartilage matrix protein; Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen | 0.503 |
ANKH | UBC | ENSP00000284268 | ENSP00000344818 | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | ubiquitin C | 0.483 |
CHST12 | ANKH | ENSP00000258711 | ENSP00000284268 | carbohydrate (chondroitin 4) sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | 0.581 |
CHST12 | CREB3L2 | ENSP00000258711 | ENSP00000329140 | carbohydrate (chondroitin 4) sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor | cAMP responsive element binding protein 3-like 2; Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity) | 0.592 |
CHST12 | KDELR3 | ENSP00000258711 | ENSP00000386918 | carbohydrate (chondroitin 4) sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity) | 0.600 |
CHST12 | MATN1 | ENSP00000258711 | ENSP00000362870 | carbohydrate (chondroitin 4) sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor | matrilin 1, cartilage matrix protein; Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen | 0.640 |
CLCNKB | ANKH | ENSP00000364831 | ENSP00000284268 | chloride channel, voltage-sensitive Kb; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | 0.757 |
CREB3L2 | ANKH | ENSP00000329140 | ENSP00000284268 | cAMP responsive element binding protein 3-like 2; Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity) | ankylosis, progressive homolog (mouse); Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter | 0.512 |
CREB3L2 | CHST12 | ENSP00000329140 | ENSP00000258711 | cAMP responsive element binding protein 3-like 2; Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity) | carbohydrate (chondroitin 4) sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor | 0.592 |
CREB3L2 | KDELR3 | ENSP00000329140 | ENSP00000386918 | cAMP responsive element binding protein 3-like 2; Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity) | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity) | 0.418 |
CREB3L2 | MATN1 | ENSP00000329140 | ENSP00000362870 | cAMP responsive element binding protein 3-like 2; Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity) | matrilin 1, cartilage matrix protein; Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen | 0.504 |
CREB3L2 | UBC | ENSP00000329140 | ENSP00000344818 | cAMP responsive element binding protein 3-like 2; Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity) | ubiquitin C | 0.620 |