PANX3 protein (Homo sapiens) - STRING network view

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PANX3

pannexin 3; Structural component of the gap junctions and the hemichannels (392 aa)

Predicted Functional Partners:

CREB1

0.808

P2RX7

0.626

GJA3

0.526

GJA1

0.509

PCDH18

0.475

SNAPC1

0.434

NEXN

0.427

FLRT2

0.415

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREB1	PANX3	ENSP00000387699	ENSP00000284288	cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells	pannexin 3; Structural component of the gap junctions and the hemichannels	0.808
FLRT2	PANX3	ENSP00000332879	ENSP00000284288	fibronectin leucine rich transmembrane protein 2; May have a function in cell adhesion and/or receptor signaling	pannexin 3; Structural component of the gap junctions and the hemichannels	0.415
GJA1	GJA3	ENSP00000282561	ENSP00000241125	gap junction protein, alpha 1, 43kDa; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity- acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural s [...]	gap junction protein, alpha 3, 46kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.739
GJA1	P2RX7	ENSP00000282561	ENSP00000442349	gap junction protein, alpha 1, 43kDa; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity- acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural s [...]	purinergic receptor P2X, ligand-gated ion channel, 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells	0.453
GJA1	PANX3	ENSP00000282561	ENSP00000284288	gap junction protein, alpha 1, 43kDa; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity- acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural s [...]	pannexin 3; Structural component of the gap junctions and the hemichannels	0.509
GJA3	GJA1	ENSP00000241125	ENSP00000282561	gap junction protein, alpha 3, 46kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	gap junction protein, alpha 1, 43kDa; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity- acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural s [...]	0.739
GJA3	PANX3	ENSP00000241125	ENSP00000284288	gap junction protein, alpha 3, 46kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	pannexin 3; Structural component of the gap junctions and the hemichannels	0.526
NEXN	PANX3	ENSP00000333938	ENSP00000284288	nexilin (F actin binding protein)	pannexin 3; Structural component of the gap junctions and the hemichannels	0.427
P2RX7	GJA1	ENSP00000442349	ENSP00000282561	purinergic receptor P2X, ligand-gated ion channel, 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells	gap junction protein, alpha 1, 43kDa; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity- acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural s [...]	0.453
P2RX7	PANX3	ENSP00000442349	ENSP00000284288	purinergic receptor P2X, ligand-gated ion channel, 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells	pannexin 3; Structural component of the gap junctions and the hemichannels	0.626
PANX3	CREB1	ENSP00000284288	ENSP00000387699	pannexin 3; Structural component of the gap junctions and the hemichannels	cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells	0.808
PANX3	FLRT2	ENSP00000284288	ENSP00000332879	pannexin 3; Structural component of the gap junctions and the hemichannels	fibronectin leucine rich transmembrane protein 2; May have a function in cell adhesion and/or receptor signaling	0.415
PANX3	GJA1	ENSP00000284288	ENSP00000282561	pannexin 3; Structural component of the gap junctions and the hemichannels	gap junction protein, alpha 1, 43kDa; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity- acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural s [...]	0.509
PANX3	GJA3	ENSP00000284288	ENSP00000241125	pannexin 3; Structural component of the gap junctions and the hemichannels	gap junction protein, alpha 3, 46kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.526
PANX3	NEXN	ENSP00000284288	ENSP00000333938	pannexin 3; Structural component of the gap junctions and the hemichannels	nexilin (F actin binding protein)	0.427
PANX3	P2RX7	ENSP00000284288	ENSP00000442349	pannexin 3; Structural component of the gap junctions and the hemichannels	purinergic receptor P2X, ligand-gated ion channel, 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells	0.626
PANX3	PCDH18	ENSP00000284288	ENSP00000355082	pannexin 3; Structural component of the gap junctions and the hemichannels	protocadherin 18; Potential calcium-dependent cell-adhesion protein	0.475
PANX3	SNAPC1	ENSP00000284288	ENSP00000216294	pannexin 3; Structural component of the gap junctions and the hemichannels	small nuclear RNA activating complex, polypeptide 1, 43kDa; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box	0.434
PCDH18	PANX3	ENSP00000355082	ENSP00000284288	protocadherin 18; Potential calcium-dependent cell-adhesion protein	pannexin 3; Structural component of the gap junctions and the hemichannels	0.475
SNAPC1	PANX3	ENSP00000216294	ENSP00000284288	small nuclear RNA activating complex, polypeptide 1, 43kDa; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box	pannexin 3; Structural component of the gap junctions and the hemichannels	0.434

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