| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARC | NRGN | ENSP00000349022 | ENSP00000284292 | activity-regulated cytoskeleton-associated protein; Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | 0.641 |
| BAX | NRGN | ENSP00000293288 | ENSP00000284292 | BCL2-associated X protein | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | 0.803 |
| BSX | NRGN | ENSP00000344285 | ENSP00000284292 | brain-specific homeobox; DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti- related peptide function and locomotory behavior in the control of energy balance (By similarity) | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | 0.610 |
| CALM1 | GAP43 | ENSP00000349467 | ENSP00000377372 | calmodulin 1 (phosphorylase kinase, delta) | growth associated protein 43; This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction | 0.826 |
| CALM1 | NRGN | ENSP00000349467 | ENSP00000284292 | calmodulin 1 (phosphorylase kinase, delta) | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | 0.626 |
| GAP43 | CALM1 | ENSP00000377372 | ENSP00000349467 | growth associated protein 43; This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction | calmodulin 1 (phosphorylase kinase, delta) | 0.826 |
| GAP43 | IQCJ | ENSP00000377372 | ENSP00000402153 | growth associated protein 43; This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction | IQ motif containing J | 0.561 |
| GAP43 | NRGN | ENSP00000377372 | ENSP00000284292 | growth associated protein 43; This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | 0.874 |
| GAP43 | SCHIP-1 | ENSP00000377372 | ENSP00000420182 | growth associated protein 43; This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction | IQCJ-SCHIP1 readthrough | 0.489 |
| IQCJ | GAP43 | ENSP00000402153 | ENSP00000377372 | IQ motif containing J | growth associated protein 43; This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction | 0.561 |
| IQCJ | NRGN | ENSP00000402153 | ENSP00000284292 | IQ motif containing J | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | 0.661 |
| NRGN | ARC | ENSP00000284292 | ENSP00000349022 | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | activity-regulated cytoskeleton-associated protein; Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration | 0.641 |
| NRGN | BAX | ENSP00000284292 | ENSP00000293288 | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | BCL2-associated X protein | 0.803 |
| NRGN | BSX | ENSP00000284292 | ENSP00000344285 | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | brain-specific homeobox; DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti- related peptide function and locomotory behavior in the control of energy balance (By similarity) | 0.610 |
| NRGN | CALM1 | ENSP00000284292 | ENSP00000349467 | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | calmodulin 1 (phosphorylase kinase, delta) | 0.626 |
| NRGN | GAP43 | ENSP00000284292 | ENSP00000377372 | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | growth associated protein 43; This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction | 0.874 |
| NRGN | IQCJ | ENSP00000284292 | ENSP00000402153 | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | IQ motif containing J | 0.661 |
| NRGN | PKM | ENSP00000284292 | ENSP00000320171 | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | pyruvate kinase, muscle | 0.836 |
| NRGN | PRKCA | ENSP00000284292 | ENSP00000408695 | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | 0.628 |
| NRGN | PRKCG | ENSP00000284292 | ENSP00000263431 | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) | protein kinase C, gamma; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma [...] | 0.624 |
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