GPR15 protein (Homo sapiens) - STRING network view

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Score

GPR15

G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection (360 aa)

Predicted Functional Partners:

TLR3

0.800

IZUMO1

0.705

NEFM

0.584

ITIH4

0.581

YWHAB

0.567

GPR115

0.552

TNFRSF8

0.507

PAX5

0.499

IL8

0.485

ERVW-1

0.480

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERVW-1	GPR15	ENSP00000419945	ENSP00000284311	endogenous retrovirus group W, member 1; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	0.480
ERVW-1	ITIH4	ENSP00000419945	ENSP00000266041	endogenous retrovirus group W, member 1; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis	inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration	0.988
GPR115	GPR15	ENSP00000283303	ENSP00000284311	G protein-coupled receptor 115; Orphan receptor	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	0.552
GPR15	ERVW-1	ENSP00000284311	ENSP00000419945	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	endogenous retrovirus group W, member 1; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis	0.480
GPR15	GPR115	ENSP00000284311	ENSP00000283303	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	G protein-coupled receptor 115; Orphan receptor	0.552
GPR15	IL8	ENSP00000284311	ENSP00000306512	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	interleukin 8	0.485
GPR15	ITIH4	ENSP00000284311	ENSP00000266041	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration	0.581
GPR15	IZUMO1	ENSP00000284311	ENSP00000327786	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	izumo sperm-egg fusion 1; Involved in the fertilization process. May be involved in the fusion of the sperm with the egg	0.705
GPR15	NEFM	ENSP00000284311	ENSP00000221166	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	neurofilament, medium polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber	0.584
GPR15	PAX5	ENSP00000284311	ENSP00000350844	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	paired box 5	0.499
GPR15	TLR3	ENSP00000284311	ENSP00000296795	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	toll-like receptor 3; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response	0.800
GPR15	TNFRSF8	ENSP00000284311	ENSP00000263932	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	tumor necrosis factor receptor superfamily, member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B	0.507
GPR15	YWHAB	ENSP00000284311	ENSP00000300161	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in bloc [...]	0.567
IL8	GPR15	ENSP00000306512	ENSP00000284311	interleukin 8	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	0.485
IL8	ITIH4	ENSP00000306512	ENSP00000266041	interleukin 8	inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration	0.412
IL8	TLR3	ENSP00000306512	ENSP00000296795	interleukin 8	toll-like receptor 3; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response	0.582
ITIH4	ERVW-1	ENSP00000266041	ENSP00000419945	inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration	endogenous retrovirus group W, member 1; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis	0.988
ITIH4	GPR15	ENSP00000266041	ENSP00000284311	inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	0.581
ITIH4	IL8	ENSP00000266041	ENSP00000306512	inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration	interleukin 8	0.412
IZUMO1	GPR15	ENSP00000327786	ENSP00000284311	izumo sperm-egg fusion 1; Involved in the fertilization process. May be involved in the fusion of the sperm with the egg	G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection	0.705

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