node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCCIP | DHX32 | ENSP00000357748 | ENSP00000284690 | BRCA2 and CDKN1A interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity) | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | 0.897 |
BCCIP | UBC | ENSP00000357748 | ENSP00000344818 | BRCA2 and CDKN1A interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity) | ubiquitin C | 0.805 |
BCCIP | UROS | ENSP00000357748 | ENSP00000357775 | BRCA2 and CDKN1A interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity) | uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) | 0.870 |
CDC40 | CWC25 | ENSP00000304370 | ENSP00000225428 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | 0.892 |
CDC40 | DHX32 | ENSP00000304370 | ENSP00000284690 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | 0.680 |
CDC40 | EIF4A3 | ENSP00000304370 | ENSP00000269349 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] | 0.729 |
CDC40 | PRPF19 | ENSP00000304370 | ENSP00000227524 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.998 |
CDC40 | SLU7 | ENSP00000304370 | ENSP00000297151 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | SLU7 splicing factor homolog (S. cerevisiae); Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3’- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3’-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation | 0.993 |
CDC40 | TFIP11 | ENSP00000304370 | ENSP00000383892 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | tuftelin interacting protein 11; May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. May also be involved in pre-mRNA splicing (By similarity) | 0.866 |
CWC25 | CDC40 | ENSP00000225428 | ENSP00000304370 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | 0.892 |
CWC25 | DHX32 | ENSP00000225428 | ENSP00000284690 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | 0.637 |
CWC25 | PRPF19 | ENSP00000225428 | ENSP00000227524 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.978 |
CWC25 | SLU7 | ENSP00000225428 | ENSP00000297151 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | SLU7 splicing factor homolog (S. cerevisiae); Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3’- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3’-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation | 0.840 |
CWC25 | TFIP11 | ENSP00000225428 | ENSP00000383892 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | tuftelin interacting protein 11; May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. May also be involved in pre-mRNA splicing (By similarity) | 0.504 |
DDX5 | DHX32 | ENSP00000225792 | ENSP00000284690 | DEAD (Asp-Glu-Ala-Asp) box helicase 5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation a [...] | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | 0.638 |
DHX32 | BCCIP | ENSP00000284690 | ENSP00000357748 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | BRCA2 and CDKN1A interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity) | 0.897 |
DHX32 | CDC40 | ENSP00000284690 | ENSP00000304370 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | 0.680 |
DHX32 | CWC25 | ENSP00000284690 | ENSP00000225428 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | 0.637 |
DHX32 | DDX5 | ENSP00000284690 | ENSP00000225792 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | DEAD (Asp-Glu-Ala-Asp) box helicase 5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation a [...] | 0.638 |
DHX32 | EIF4A3 | ENSP00000284690 | ENSP00000269349 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] | 0.671 |