| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCA1 | PDLIM3 | ENSP00000363868 | ENSP00000284770 | ATP-binding cassette, sub-family A (ABC1), member 1 | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | 0.576 |
| ACTN1 | ACTN2 | ENSP00000377941 | ENSP00000355537 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.999 |
| ACTN1 | ACTN4 | ENSP00000377941 | ENSP00000252699 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | actinin, alpha 4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation | 0.999 |
| ACTN1 | PDLIM3 | ENSP00000377941 | ENSP00000284770 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | 0.630 |
| ACTN2 | ACTN1 | ENSP00000355537 | ENSP00000377941 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.999 |
| ACTN2 | ACTN4 | ENSP00000355537 | ENSP00000252699 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | actinin, alpha 4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation | 0.999 |
| ACTN2 | PDLIM3 | ENSP00000355537 | ENSP00000284770 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | 0.745 |
| ACTN4 | ACTN1 | ENSP00000252699 | ENSP00000377941 | actinin, alpha 4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.999 |
| ACTN4 | ACTN2 | ENSP00000252699 | ENSP00000355537 | actinin, alpha 4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.999 |
| ACTN4 | PDLIM3 | ENSP00000252699 | ENSP00000284770 | actinin, alpha 4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | 0.613 |
| BCKDHB | PDLIM3 | ENSP00000318351 | ENSP00000284770 | branched chain keto acid dehydrogenase E1, beta polypeptide; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components- branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | 0.545 |
| CAMKK1 | PDLIM3 | ENSP00000158166 | ENSP00000284770 | calcium/calmodulin-dependent protein kinase kinase 1, alpha; Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | 0.597 |
| HSP90AA1 | HSP90AB1 | ENSP00000335153 | ENSP00000325875 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.999 |
| HSP90AA1 | PDLIM3 | ENSP00000335153 | ENSP00000284770 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | 0.507 |
| HSP90AB1 | HSP90AA1 | ENSP00000325875 | ENSP00000335153 | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.999 |
| HSP90AB1 | PDLIM3 | ENSP00000325875 | ENSP00000284770 | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | 0.507 |
| JUP | PDLIM3 | ENSP00000311113 | ENSP00000284770 | junction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhes [...] | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | 0.517 |
| PDLIM3 | ABCA1 | ENSP00000284770 | ENSP00000363868 | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.576 |
| PDLIM3 | ACTN1 | ENSP00000284770 | ENSP00000377941 | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.630 |
| PDLIM3 | ACTN2 | ENSP00000284770 | ENSP00000355537 | PDZ and LIM domain 3; May play a role in the organization of actin filament arrays within muscle cells (By similarity) | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.745 |
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