| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAN | ADAMTS5 | ENSP00000387356 | ENSP00000284987 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | 0.998 |
| ACAN | ADAMTS7 | ENSP00000387356 | ENSP00000373472 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP | 0.480 |
| ACAN | BCAN | ENSP00000387356 | ENSP00000331210 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans | 0.917 |
| ACAN | MMP13 | ENSP00000387356 | ENSP00000260302 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | matrix metallopeptidase 13 (collagenase 3); Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process | 0.728 |
| ACAN | THBS1 | ENSP00000387356 | ENSP00000260356 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.416 |
| ADAMTS5 | ACAN | ENSP00000284987 | ENSP00000387356 | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | 0.998 |
| ADAMTS5 | ADAMTS7 | ENSP00000284987 | ENSP00000373472 | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP | 0.916 |
| ADAMTS5 | ADAMTSL1 | ENSP00000284987 | ENSP00000369921 | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | ADAMTS-like 1 | 0.912 |
| ADAMTS5 | ADAMTSL4 | ENSP00000284987 | ENSP00000271643 | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis | 0.906 |
| ADAMTS5 | B3GALTL | ENSP00000284987 | ENSP00000343002 | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | beta 1,3-galactosyltransferase-like; O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan | 0.900 |
| ADAMTS5 | BCAN | ENSP00000284987 | ENSP00000331210 | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans | 0.956 |
| ADAMTS5 | CFP | ENSP00000284987 | ENSP00000247153 | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes | 0.906 |
| ADAMTS5 | MMP13 | ENSP00000284987 | ENSP00000260302 | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | matrix metallopeptidase 13 (collagenase 3); Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process | 0.883 |
| ADAMTS5 | POFUT2 | ENSP00000284987 | ENSP00000339613 | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...] | 0.910 |
| ADAMTS5 | THBS1 | ENSP00000284987 | ENSP00000260356 | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.915 |
| ADAMTS7 | ACAN | ENSP00000373472 | ENSP00000387356 | ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | 0.480 |
| ADAMTS7 | ADAMTS5 | ENSP00000373472 | ENSP00000284987 | ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP | ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period | 0.916 |
| ADAMTS7 | ADAMTSL1 | ENSP00000373472 | ENSP00000369921 | ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP | ADAMTS-like 1 | 0.913 |
| ADAMTS7 | ADAMTSL4 | ENSP00000373472 | ENSP00000271643 | ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP | ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis | 0.904 |
| ADAMTS7 | B3GALTL | ENSP00000373472 | ENSP00000343002 | ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP | beta 1,3-galactosyltransferase-like; O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan | 0.900 |
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