| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGAP23 | FGD5 | ENSP00000393539 | ENSP00000285046 | Rho GTPase activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | 0.559 |
| C19orf55 | FGD5 | ENSP00000380116 | ENSP00000285046 | chromosome 19 open reading frame 55 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | 0.567 |
| FGD5 | ARHGAP23 | ENSP00000285046 | ENSP00000393539 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | Rho GTPase activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) | 0.559 |
| FGD5 | C19orf55 | ENSP00000285046 | ENSP00000380116 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | chromosome 19 open reading frame 55 | 0.567 |
| FGD5 | LDB1 | ENSP00000285046 | ENSP00000392466 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | 0.465 |
| FGD5 | LDB2 | ENSP00000285046 | ENSP00000306772 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | 0.512 |
| FGD5 | LRCH4 | ENSP00000285046 | ENSP00000309689 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | leucine-rich repeats and calponin homology (CH) domain containing 4 | 0.534 |
| FGD5 | LRRC3B | ENSP00000285046 | ENSP00000379880 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | leucine rich repeat containing 3B | 0.566 |
| FGD5 | LRRN1 | ENSP00000285046 | ENSP00000314901 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | leucine rich repeat neuronal 1 | 0.503 |
| FGD5 | SH3GL3 | ENSP00000285046 | ENSP00000391372 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | SH3-domain GRB2-like 3; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity) | 0.465 |
| FGD5 | TOPAZ1 | ENSP00000285046 | ENSP00000310303 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | testis and ovary specific PAZ domain containing 1 | 0.649 |
| FGD5 | TTC21A | ENSP00000285046 | ENSP00000398211 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | tetratricopeptide repeat domain 21A | 0.450 |
| LDB1 | FGD5 | ENSP00000392466 | ENSP00000285046 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | 0.465 |
| LDB2 | FGD5 | ENSP00000306772 | ENSP00000285046 | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | 0.512 |
| LRCH4 | FGD5 | ENSP00000309689 | ENSP00000285046 | leucine-rich repeats and calponin homology (CH) domain containing 4 | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | 0.534 |
| LRCH4 | LRRC3B | ENSP00000309689 | ENSP00000379880 | leucine-rich repeats and calponin homology (CH) domain containing 4 | leucine rich repeat containing 3B | 0.509 |
| LRCH4 | TOPAZ1 | ENSP00000309689 | ENSP00000310303 | leucine-rich repeats and calponin homology (CH) domain containing 4 | testis and ovary specific PAZ domain containing 1 | 0.586 |
| LRCH4 | TTC21A | ENSP00000309689 | ENSP00000398211 | leucine-rich repeats and calponin homology (CH) domain containing 4 | tetratricopeptide repeat domain 21A | 0.501 |
| LRRC3B | FGD5 | ENSP00000379880 | ENSP00000285046 | leucine rich repeat containing 3B | FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape | 0.566 |
| LRRC3B | LRCH4 | ENSP00000379880 | ENSP00000309689 | leucine rich repeat containing 3B | leucine-rich repeats and calponin homology (CH) domain containing 4 | 0.509 |
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