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STRINGSTRING
NFE2L2 NFE2L2 ID4 ID4 UBC UBC ABCC3 ABCC3 SLC10A2 SLC10A2 ALB ALB SLCO1A2 SLCO1A2 FABP6 FABP6 SLCO1B1 SLCO1B1 SLC10A1 SLC10A1 SLCO1B3 SLCO1B3
"ABCC3" - ATP-binding cassette, sub-family C in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
ABCC3ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (1527 aa)    
Predicted Functional Partners:
SLCO1B1
solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver (691 aa)
          score_image score_image   0.977
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium (349 aa)
          score_image score_image   0.975
SLCO1B3
solute carrier organic anion transporter family, member 1B3; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver (702 aa)
          score_image score_image   0.974
SLCO1A2
solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin (670 aa)
          score_image score_image   0.973
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (348 aa)
          score_image score_image   0.957
FABP6
fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis (177 aa)
          score_image score_image   0.933
ALB
albumin (609 aa)
          score_image score_image   0.925
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.912
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein; ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding (161 aa)
            score_image   0.885
NFE2L2
nuclear factor (erythroid-derived 2)-like 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (605 aa)
            score_image   0.855
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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