node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CA2 | PGR | ENSP00000285379 | ENSP00000325120 | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation | 0.877 |
CA2 | SLC26A3 | ENSP00000285379 | ENSP00000345873 | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | 0.876 |
CA2 | SLC26A4 | ENSP00000285379 | ENSP00000265715 | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | solute carrier family 26, member 4; Sodium-independent transporter of chloride and iodide | 0.897 |
CA2 | SLC26A6 | ENSP00000285379 | ENSP00000378920 | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | solute carrier family 26, member 6; Does not seem to be involved in anion transport | 0.877 |
CA2 | SLC4A1 | ENSP00000285379 | ENSP00000262418 | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin | 0.974 |
CA2 | SLC4A2 | ENSP00000285379 | ENSP00000405600 | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1); Plasma membrane anion exchange protein of wide distribution | 0.941 |
CA2 | SLC4A4 | ENSP00000285379 | ENSP00000393557 | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | solute carrier family 4, sodium bicarbonate cotransporter, member 4 | 0.967 |
CA2 | SLC4A7 | ENSP00000285379 | ENSP00000295736 | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.889 |
CA2 | SLC4A8 | ENSP00000285379 | ENSP00000405812 | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | solute carrier family 4, sodium bicarbonate cotransporter, member 8; Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+)-HCO3(-) stoichiometry of 2-1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity | 0.959 |
CA2 | SLC9A1 | ENSP00000285379 | ENSP00000263980 | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | 0.981 |
PGR | CA2 | ENSP00000325120 | ENSP00000285379 | progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | 0.877 |
SLC26A3 | CA2 | ENSP00000345873 | ENSP00000285379 | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | 0.876 |
SLC26A3 | SLC4A1 | ENSP00000345873 | ENSP00000262418 | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin | 0.585 |
SLC26A3 | SLC4A2 | ENSP00000345873 | ENSP00000405600 | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1); Plasma membrane anion exchange protein of wide distribution | 0.657 |
SLC26A3 | SLC4A4 | ENSP00000345873 | ENSP00000393557 | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | solute carrier family 4, sodium bicarbonate cotransporter, member 4 | 0.728 |
SLC26A3 | SLC4A7 | ENSP00000345873 | ENSP00000295736 | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.575 |
SLC26A3 | SLC4A8 | ENSP00000345873 | ENSP00000405812 | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | solute carrier family 4, sodium bicarbonate cotransporter, member 8; Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+)-HCO3(-) stoichiometry of 2-1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity | 0.680 |
SLC26A3 | SLC9A1 | ENSP00000345873 | ENSP00000263980 | solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction | 0.527 |
SLC26A4 | CA2 | ENSP00000265715 | ENSP00000285379 | solute carrier family 26, member 4; Sodium-independent transporter of chloride and iodide | carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye | 0.897 |
SLC26A4 | SLC4A1 | ENSP00000265715 | ENSP00000262418 | solute carrier family 26, member 4; Sodium-independent transporter of chloride and iodide | solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin | 0.657 |