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SLC4A2 SLC4A2 SLC9A1 SLC9A1 SLC4A8 SLC4A8 SLC26A3 SLC26A3 PGR PGR CA2 CA2 SLC26A6 SLC26A6 SLC26A4 SLC26A4 SLC4A4 SLC4A4 SLC4A7 SLC4A7 SLC4A1 SLC4A1
"CA2" - carbonic anhydrase II in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Predicted Interactions
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protein homology
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CA2carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye (260 aa)    
Predicted Functional Partners:
SLC9A1
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (815 aa)
        score_image   score_image   0.981
SLC4A1
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin (911 aa)
        score_image   score_image   0.974
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4 (1094 aa)
        score_image   score_image   0.967
SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8; Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+)-HCO3(-) stoichiometry of 2-1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity (1093 aa)
        score_image   score_image   0.959
SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1); Plasma membrane anion exchange protein of wide distribution (1241 aa)
        score_image   score_image   0.941
SLC26A4
solute carrier family 26, member 4; Sodium-independent transporter of chloride and iodide (780 aa)
            score_image   0.897
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7 (1214 aa)
            score_image   0.889
SLC26A6
solute carrier family 26, member 6; Does not seem to be involved in anion transport (759 aa)
            score_image   0.877
PGR
progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation (933 aa)
            score_image   0.877
SLC26A3
solute carrier family 26, member 3; Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis (764 aa)
            score_image   0.876
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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